Situated in the heart of The University of Texas at Austin campus, the college primarily makes its home in the two-building pharmacy complex that includes the north, or original pharmacy building, and the south building. Between the two buildings is a courtyard that serves as a gathering space for many college events. Additionally, the two buildings are connected by walkways on the third and fourth levels.

In addition to well-equipped classrooms, laboratories and offices, the pharmacy complex provides two classrooms used for interactive distance learning; and pharmaceutical technology laboratories with facilities for product development, pilot manufacturing, sterile production and quality control, and stability testing. The south building houses a student computer laboratory and a computer teaching lab, and a separate lab devoted to helping students and faculty develop presentations and curriculum using the latest in instructional technology. Some rooms within the complex are available for use by specific groups, and pharmacy faculty, staff and students may request room reservations by completing an on-line request form.

The College's Divisions of Medicinal Chemistry and Pharmacology & Toxicology make their home in the Biomedical Engineering Building, just a short distance away from the original two building complex The Forty Acres Pharmacy, the campus pharmacy supporting university health services, is located in the Student Services Building. Operations of the pharmacy is under the direction of the college administration and the facility serves as a teaching laboratory for fourth-year professional pharmacy students while providing comprehensive pharmaceutical services to the UT community.

The Dell Pediatric Research Institute (DPRI), located a short distance up I35 from the central campus, is home to some of the college's faculty.

The University of Texas Health Science Center at San Antonio has provided facilities for the education and training of pharmacy students, residents and fellows since 1972. The McDermott Clinical Sciences Building on the Health Science Center campus houses faculty and staff in the college's Division of Pharmacotherapy. Within the space is a state-or-the art interactive television classroom, a small classroom, two conference rooms, a student lounge and more than 6,000 square feet of research lab space. The Drug Information Service is located within the Briscoe Library on the main San Antonio campus.

Students in the college's cooperative program are supported by facilities at either the University of Texas at El Paso or the University of Texas-Pan American in the Rio Grande Valley of south Texas.  These campuses maintain state-of-the-art technology that promotes a quality learning experience and provides a vital link to the UT Austin campus.  Cooperative program students complete their first two pre-pharmacy academic years at their home campus, come to Austin for the for the first two professional years, and return to their home campuses for the final two years of the program.