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TherapeUTex

THERAPEUTEX Services and Capabilities

The goal of the THERAPEUTEX Preclinical Core Lab is to characterize properties of new therapeutic compounds in animal models by focusing on drug delivery and pharmacokinetic/pharmacodynamic (PK/PD) studies. Efforts include drug formulation and optimization of delivery method as well as development of various disease related animal models with expertise in infectious disease and cancer/angiogenesis, evaluation of optimal drug concentrations, toxicity, efficacy, and target validation by tissue analysis of drug accumulation, metabolism, and elimination.


Drug Formulation Characterization

THERAPEUTEX offers a variety of methods to characterize the physicochemical properties of pharmaceutical materials.  These techniques can be applied for pre-formulation, formulation, or device testing.  Inhaled formulation characterization is a specific area where THERAPEUTEX has extensive resources and a high level of expertise.

  • USP Dissolution  
  • HPLC analysis 
  • Geometric Particle Size Analysis (micron and submicron)
    -Inhalation Cell and Wet Sample Dispersion Unit
  • Aerodynamic Particle Size Analysis
  • Aerosol Dose Uniformity
  • Differential Scanning Calorimetry
  • Rheometry
  • Texture Analysis
  • Powder Flowability
  • Bulk, Tap, and True Density
  • Moisture Sorption
  • Powder Surface Energy Characterization
  • Atomic Force Microscopy

Preclinical and Proof-of-Concept Studies

The THERAPEUTEX Preclinical Core Lab can help transition compound studies to the next level of preclinical and proof-of-concept studies.  With faculty and staff expertise in pulmonary disease, cancer/angiogenesis, and infectious disease, the
THERAPEUTEX team can help with nearly all aspects of the study, including: experimental design and implementation, animal colony management and genotyping, surgical technique, and data analysis.

  • Rodent Vivarium with General Husbandry
  • Ectopic and Orthotopic Tumor Models
  • Rodent Drug Delivery
    -Routes include intravenous (tail vein, jugular cannulation), subcutaneous, intraperitoneal, intramuscular, oral gavage
    - Nose-only pulmonary dosing
  • Rodent Surgery and Blood Collection
  • Tumor 3D Histoculture
  • Cell Culture
    - Pulmonary and cancer cell lines
    - Viability, proliferation, and cytotoxicity assays
  • Microplate Photometer
  • Horizontal and Vertical Electrophoresis
  • Polymerase Chain Reaction
  • Western Blotting
  • Refrigerated Clinical Benchtop Centrifuge and Refrigerated MicroCentrifuge 
  • Stereomicroscope System
    - Whole tissue/animal and live cell imaging with imaging software 
  • Cryogenic Storage, Chromatography Refrigerator, Enzyme/Lab Freezer, Ulra Low Freezer

Lab-Scale Formulation Production

THERAPEUTEX also offers small scale formulation production for use in R&D studies.  Some of the production capabilities include the following:

  • Mechanical particle size reduction (ball milling, jet milling, high pressure homogenization, cryogenic)
  • Tableting
  • Lyophilization
  • pMDI packaging
  • Stability chambers

Histology Services

Once tissue and blood samples have been collected, several different forms of target validation by analysis of drug accumulation, metabolism, and elimination can be evaluated.

  • Tissue Processing
  • Paraffin and Glycol Methacrylate Embedding 
  • Microtome and Cryotome Sectioning
  • Immunostaining (IHC and ICC) and Custom Staining
  • Inverted Fluorescent Microscope with Imaging Software 
   

TherapeUTex
Our goal is to aid the progression of drug products and technologies through the development process by providing services including drug formulation and delivery, in vitro and in vivo preclinical and proof-of-concept studies, histological preparation, and lab-scale formulation and production.
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TherapeUTex
We've built the regulatory environment necessary to meet FDA requirements for drug evaluation. And, we've assembled the scientific expertise to design effective studies. Our goal is to assist researchers by providing the studies required for a successful FDA submission.
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TherapeUTex
The UTech Dorm Room provides wet lab space for Austin's bioscience community.
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