Patrick J. Davis, Ph.D.

COLLEGE OF PHARMACY

THE UNIVERSITY OF TEXAS AT AUSTIN

 

Office of the Associate Dean for Academic Affairs € PHR 5.112D € Austin, Texas 78712-1074

Campus Mail Code A1900 TEL (512) 475-9751 € FAX (512) 232-1893 €
Email: davispj@mail.utexas.edu

 

Pharmacotherapy II (PHR 675E)

Spring 2011, MWF 10-12 a.m.

Respiratory & Infectious Diseases Modules – First Day Handout

 

Faculty:                           Dr. Shawn Bratton, Ph.D. (Pharmacology/Toxicology)

                                          Dr. David Burgess, Pharm.D. (Pharmacotherapy)

                                          Dr. Patrick Davis, Ph.D. (Med Chem), Course Coordinator

                                          Dr. John Digiovanni, Ph.D. (Pharmacology/Toxicology)

                                          Dr. Christopher Frei, Pharm.D. (Pharmacotherapy)

                                          Dr. Nicholas Forcade, Pharm.D. (Pharmacotherapy)

                                          Dr. Jim Karboski, Pharm.D. (Pharmacy Practice)

                                          Dr. Sean Kerwin, Ph.D. (Med Chem)

                                          Prof. Jim Koeller, M.S. (Pharmacotherapy)

                                          Dr. Dannielle O¹Donnell, Pharm.D. (Pharmacy Practice)

                             Dr. Robert Talbert, Pharm.D. (Pharmacotherapy)

                                          Dr. Nathan Wiederhold, Pharm.D. (Pharmacotherapy)

                                          Dr. Jonathon Zhang, Ph.D. (Med Chem)

                               

 

Course Texts:         1.   Goodman & Gilman, Pharmacol. Basis of Therapeutics, 11th Edition, 2005.

                                          [Available Online]

2.     Dipiro, Talbert, Yee, et al. Pharmacotherapy: A Pathophysiologic Approach, 7th. Edition, Appleton & Lange, 2008. [Available Online]

3.     Foye, Principles of Medicinal Chemistry, 6th (2007) Edition Lippincott, 2007.

                                    Note: Exam questions may come from assigned text or web-based readings.

Web Resources:    1.   The official Blackboard® web site for this course can be accessed either through UTDirect or via http://courses.utexas.edu. Either access point is UTEID-protected, and provides you links to the courses in which you are currently enrolled (make sure you access the correct Pharmacotherapy course since you are enrolled in three such courses). You are strongly encouraged to visit this site for additional resources associated with this course (your grades, electronic quizzes, powerpoint presentation, previous exams, the discussion board, contacting faculty by Email, electronic versions of suggested and required readings and hyperlinks).

    The website will also be used for official, course-related announcements and for exchange class information and questions via the discussion board. Be aware that any message posted to the discussion board are available to all enrolled students and faculty.

 

    If you encounter problems with accessing Blackboard® please contact the ITS helpdesk at: 512-475-9400 or the FAQ¹s at www.utexas.edu/academic/blackboard/answers

 

2. You may also contact faculty members directly via phone or Email.

Dr. Shawn Bratton-(512 471-1735) sbbratton@mail.utexase.du
Dr. David Burgess (210-567-8355) burgessd@uthscsa.edu
Dr. Patrick Davis (475-9751; 892-3660) davispj@mail.utexas.edu
Dr. John Digiovanni (
512 495 4726) jdigiovani@mailutexas.edu

Dr. Christopher Frei (210-567-8355) freic@uthscsa.edu

Dr. Nicholas Forcade (210-567-8355) nforcade@mail.utexas.edu
Dr. Jim Karboski (
512 232 2628) karboski@mail.utexas.edu
Dr. Sean Kerwin (512-471-5074) skerwin@mail.utexas.edu
Prof. Jim Koeller (210-567-8355) koeller@uthscsa.edu
Dr. Dannielle O¹Donnell (512-248-8099) odonnell@mail.utexas.edu
Dr. Robert Talbert (210-567-8355) talbert@uthscsa.edu
Dr. Nathan Wiederhold (210-567-8355) wiederholdn@uthscsa.edu

Dr. Jonathon Zhang (512-471-4551 zhang@mail.utexas.edu

Faculty are expected to inform students concerning their office hours (including electronic office hours, if appropriate) during their first lectures in

the course.

 

3. Taped and video-streamed recordings of lectures are intended to facilitate learning for those students who find this type of supplementation useful; they are not a substitute for attending class. Although recordings of these lectures will initially be available to you for the semester, this is for supplementation only; your instructors expect you to attend all scheduled lectures. If attendance becomes an issue, videostreaming availability may

be reduced to a two-week period following the lecture. If an individual faculty member chooses to not make his/her lectures available by videotape and/or videostreaming, it is that faculty member¹s responsibility to so inform you. It is also faculty prerogative as to whether to administer announced or unannounced quizzes during lectures (be sure to bring your classroom response system (CRS) ³clickers² to each and every class). If a faculty member chooses to do so, the points for these quizzes will replace questions on their portion of the upcoming exam.

 

Viewing video-streamed recordings of lectures is primarily intended for on-campus computer facilities (e.g., LRC Library, 3.116 computer lab, or other computer facilities available on your specific campus). However, it should be possible to view the streaming video off-campus using RoadRunner® or DSL broadband connections. Your faculty are not in a position to troubleshoot your video-streaming problems, so please do not ask them to do so; rather, you should access the LRC website at http://www.utexas.edu/pharmacy/resources/lrc to address those problems. Any

other questions should be go to the Director of the LRC, Kamran Zias (ziai@austin.utexas.edu)

 

Spring 2011, MWF 10-12, PHR 3.106

Respiratory & Infectious Diseases Lecture Schedule

 

Lec

Faculty

Date(s)

Topic

15 min

Davis

Jan 19

Course Intro – Syllabus Coverage

 

 

 

 

 

 

 

RESPIRATORY MODULE [18 lectures]

3

Bratton

Jan 19, 19, 21

Immunological Basis of Allergy

1

Bratton

21

Pharmacology of Antihistamines

2

Bratton

24, 24

Etiology of Asthma

2

Karboski

26, 26

Allergic Rhinitis

2

Zhang

28, 28

Med Chem of Antihistamines

2

Bratton

31, 31

Adrenergics & Beta-Adrenergics in Asthma

1

Bratton

Feb 2

Pharmacology of Anti-inflammatory Corticosteroids

1

Zhang

2

Med Chem of Anti-inflammatory Corticosteroids

1

Zhang

4

Med Chem Adrenergics

2

Talbert

4, 7

Asthma

1

Talbert

7

COPD

 

 

 

Exam #1 Respiratory Module (18 lectures; 144 pts) held on Feb 16th

 

 

 

 

 

 

 

ANTIBACTERIALS MODULE [43 lectures]

 

 

 

General Concepts in Antimicrobial Therapy

0.5

Davis

Feb 9

Introduction to the Antimicrobials Module (Road Map)

 

1.5

Davis

9, 9

Resistance Development to Antimicrobials

1

Davis

11

Classification of Antibiotics a/c Mode of Action

1

Burgess

11

Review of Medical Microbiology

1

Burgess

14

Sensitivity Testing

2

Burgess

14, 18

General Principles of Antimicrobial Therapy

 

 

 

 

 

 

 

Antimicrobial Classes & Introduction to
       Their Therapeutic Applications

8

Davis

18,21,21,23,23,25,25,28

Cell Wall Synthesis Inhibitors

3

Burgess

28, Mar 2, 2

Intro to Clinical Pharmacology of b-Lactams

 

 

 

 

Exam #2 Antibacterials Module (18 lectures; 144 pts) held on Mar 9th

 

 

 

 

3

Davis

4, 4, 7

Protein Synthesis Inhibitors

3

Burgess

7, 11, 11

Intro to Clinical Pharmacol of Protein Synth Inhib

 

 

 

SPRING BREAK MARCH 14-19

1

Davis

21

Inhibitors of Nucleic Acid Synthesis or Function

1

Davis

21

Inhibitors of Folate Synthesis (sulfonamides, trimethoprim) and Misc Agents

 

2

Burgess

23, 23

Inhibitors of Nucleic Acid Synthesis or Function; Inhibitors of Folate Synthesis (sulfonamides, trimethoprim) and Misc Agents

 

 

 

 

 

 

 

Therapeutic Management of Disease States

1

Burgess

25

Intro to Pharmacodynamics of Antimicrobial Agents

 

 

 

 

Exam #3 Antibacterials Module (11 lectures; 88 pts) held on Mar 30th

 

 

 

 

1

Burgess

25

Surgical Prophylaxis

1

Frei

28

Skin & Soft Tissue Infections

1

Burgess

28

Bone & Joint Infections

1

Burgess

April 1

Upper Respiratory Tract Infections

1

Burgess

1

Meningitis

1

Burgess

4

Tuberculsosis

1

O¹Donnell

4

Sexually Transmitted Diseases

1

Burgess

6

Hospital-Acquired Pneumonia

1

Burgess

6

Community-Acquired Pneumonia

1

Burgess

8

GI & Intra-Abdominal Infections

1

Burgess

8

Urinary Tract Infections

1

Burgess

11

Endocarditis

1

Forcade

11

Sepsis

1

Burgess or Peds Faculty

13

Cystic Fibrosis

 

 

 

Exam #4 Antibacterials Module (14 lectures; 112 pts) held on Ap 20th

 

 

 

 

 

 

 

NON-BACTERIAL INFECTIOUS DISEASES MODULE [20 lectures]

2

Koeller

Ap 15, 15

Immunopharmacology

 

 

 

 

1

Davis

18

Antifungal Antibiotics

1

Wiederhold

18

Intro to Fungal Infections

2

Wiederhold

22, 22

Antifungal Therapeutics

2

Wiederhold

25, 25

Parasitic Diseases and Their Treatment

2

Digiovanni

27, 27

Antiviral Pharmacology

2

Kerwin

29,29

Med Chem of Antiviral Agents

 

 

 

Exam #5 Non-Bacterial ID Module (12 lectures; 96 pts) held on May 4th

 

 

 

 

3

Faculty TBD

May 2, 2, 4

AIDS & Associated Opportunistic Infections

3

Wiederhold

4, 6, 6

Non-HIV Viral Infections (including Hepatitis)

 

 

 

Last 6 lectures (48 pts) covered on non-cumulative part of final

 

 

Final Exam, which will include the last 5 lectures, date to be announced

 


Pharmacotherapy II (PHR 675E)

Course Policies

Examinations:

 

There will be five-110 minute summary examinations throughout the semester, plus a comprehensive final administered during the Final Exam. Semester exams will

be given on Wednesday mornings from 8:00-9:50 am, in Welch Hall (WEL 2.224) according to the following schedule:

 

Exam Date & Time

Location

Coverage

Faculty

Points

Wed, Feb 16, 8AM

WEL 2.224

Respiratory

Module I

Bratton, Karboski, Zhang, Talbert [

144

Wed, Mar 9, 8AM

WEL 2.224

Bacterial ID

Davis, Burgess

144

Wed, Mar 30, 8AM

WEL 2.224

Bacterial ID

Davis, Burgess

88

Wed, April 20, 8AM

WEL 2.224

Bacterial ID

Burgess, Frei, O¹Donnell, Forcade

112

Wed, May 4, 8AM

WEL 2.224

Non-bacterial ID

Koeller, Davis, Wiederhold, Digiovani, Kerwin

96

Final Exam

May 11-17

TBA

Non-bacterial &
Cumulative

TBD, Wiederhold

All Faculty

48
146

 

Exam weighting is based upon the number of lectures applying to that exam. The five summary exams will consist of four-2 pt questions per lecture hour; the final will consist of two-1pt questions per lecture hour. (Total = 778 pts). The format and emphasis for exams is entirely the prerogative of the faculty, irrespective of exam format and emphasis in previous exams.

 

It is also faculty prerogative as to whether to administer announced or unannounced quizzes during lectures (be sure to bring your classroom response system (CRS) ³clickers² to each and every class). If a faculty member chooses to do so, the points for these quizzes will replace questions on their portion of the upcoming exam.


Students must arrive on time for examinations.
All instructions and corrections will be made at the beginning of the examination period and will not be repeated. Semester exams will begin promptly at the designated hour and will be picked up after exactly 90 minutes. The final examination will last three hours. Students arriving after any students have completed the exam and left the room may not be allowed to sit for the exam, and may receive a score of zero for the exam.

 

No allowances will be made for an exam being missed, other than documented illness or emergency. The student must contact the course coordinator for confirmation prior to the exam. If permission is granted to delay the exam, it is the student responsibility to complete the College Form titled ³Student Request for Alternate Exam Time² for final consideration and final approval by the Faculty member. In this event, the nature of the make-up will be at the discretion of the course coordinator (oral, written, increased weighting on the final, etc.). An unexcused absence from an exam may result in a grade of "zero" for that exam.

 

The grading of objective questions will be based upon the scantron sheets turned in; i.e., not on answers written on the exam papers. After the exams have been graded and an item analysis performed (Measurement & Evaluation Center), questions may be discarded or otherwise adjusted at the discretion of the Course Coordinator in consultation with the faculty before arriving at final grades.

 

Return of Exams; Posting Class Scores & Keys:

 

Your summary examination and scantron copy will be returned to you within a reasonable time after taking the exam. Following the grading of each exam, the exam key will be posted as an ³Announcement² on the Blackboard® course website. Individual student scores can be accessed using the Blackboard® ³Gradebook² (only you have access to your grades), and individual grades will not be publicly posted in any manner.

 

Post-Exam Remarks and Reconsideration Requests:

 

If there is a disagreement over the answer to a specific question, the student should present his/her exam plus a written explanation (with appropriate documentation) to the instructor within 72 hours of the listserv announcement of posting of the exam results & key as described above. Documentation may include statements from textbooks, handouts, packets, or current scientific reprints; lecture notes are not authoritative documentation. The explanation must be clear, rational, and concise. (This policy does not apply to addition or other grading errors). Copy the course coordinator (Dr. Davis) on your email submissions. Note that faculty are instructed to not respond to reconsideration requests until the deadline has passed, so do not expect an immediate response to your request (be patient).

 

Final Exam Re-Examination Policy:

 

The re-examination policy for this course will follow the General Information Catalog (GIC) and College of Pharmacy policies for the University, which reads as follows: ³Only a student who has a grade average of at least a C on all class work and lab work submitted before the final exam (in this course, >70% on each exam) may request a temporary delay of the final course grade because he or she failed the final examination (i.e., <65%), which is the examination given during the final exam period as printed in the official examination schedule. If the petition is denied by the instructor, the student¹s final course grade will remain as originally determined. If the petition is granted by the instructor, the grade on the reexamination will be substituted for the grade on the original exam in determining the student¹s final course grade, provided the student earns at least a C on the reexamination. If the grade on the reexamination is less than a C(-) (in this course, <70%), a final course grade of F must be recorded.²

 

All students who are eligible for re-examination according to the University criteria specified above will be notified by the Course Coordinator within 24 hrs of posting the final examination scores, and must reply within the specified time as to whether they will be taking the re-examination. Those students who choose to take the re-examination will be awarded a course grade of ³X² until the re-examination is evaluated and the final course grade computed.

 

Module Mastery:

 

Because of the importance of each and every therapeutic module, a student doing very well on one module while failing another module (and having an overall average that would be passing) is no longer acceptable. There are three modules in this course, and students must pass each and every module with a grade of at least 70% in order to pass the course. If a module is not passed on the summary exam(s), that portion of the comprehensive final will be scrutinized to assess whether the student has finally mastered the material. If the student does not achieve 70% on that portion of the comprehensive final with this second attempt, a course grade of ³F² will be assigned. . If the student does demonstrate mastery, the score originally attained on the summary exam still applies (i.e., the first score earned) and will be used to calculate the final course grade. For those students who do not demonstrate module mastery on material involving the non-cumulative portion of the final exam, there will be one makup exam given over just that material. The student must pass this second opportunity to demonstrate module mastery or a grade of F will be assigned an F in the course. If the student does pass this second opportunity to demonstrate module mastery (by score 70% or higher), a score of 70% (a minimum passing grade) will be used in the calculating the module. The best advice is to achieve a passing score on the module in the first place, and if not, make sure that you review your errors on the summary exam(s) with the appropriate faculty to address any deficiencies before the final.

 

Course Grading:

 

            A Range:                                             A = 100%-93%           A- = 92%-90%

            B Range:        B+ = 89%-87%           B = 86%-83%             B- = 82%-80%

            C Range:         C+ = 79%-77%           C = 76%-73%             C- = 72%-70%

            D Range:         D+ = 69%-67%          D = 66%-65%

            F =      Below 65%

 

This scale may be curved more leniently in the final analysis of grades at the discretion of the instructors.

 

Academic Integrity:

 

The ³Statement on Scholastic Integrity of the College of Pharmacy² reads as follows: "Pharmacy practitioners enjoy a special trust and authority based upon the profession's commitment to a code of ethical behavior in its management of client affairs. The inculcation of a sense of responsible professional behavior is a critical component of professional education, and high standards of ethical conduct are expected of pharmacy students. Students who violate University rules on scholastic dishonesty are subject to disciplinary penalties, including failure of the course involved and dismissal from the college and/or the University. Since dishonesty harms the individual, fellow students, and the integrity of the University and the College of pharmacy, policies of scholastic dishonesty will be strictly enforced in this class".

 

Students are expected to work independently on all examinations. Any student caught cheating will be given an "zero" on the exam (minimum). Any student suspected of dishonesty will be reported to the Dean of the College of Pharmacy and to the Dean of Students, as per University regulations. Students are expected to have read and understood the current issue of the General Information Catalog published by the Registrar's Office for information about procedures and about what constitutes scholastic dishonesty.

 

Students with Disabilities:

 

The University of Texas at Austin provides upon request appropriate academic accommodations for qualified students with disabilities. All University rules concerning accommodations must be followed, including the student arranging for special accommodations prior to each examination. In the absence of such prearrangement, it will be assumed that the student is not requesting special accommodations for that exam, and will be expected to take the exam with the rest of the class at the regularly scheduled exam time. For more information, contact the Office of the Dean of Students at 471-6259, 471-4641 TTY.