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Patrick J. Davis, Ph.D. COLLEGE OF PHARMACY THE UNIVERSITY OF TEXAS AT AUSTIN Office
of the Associate Dean for Academic Affairs ¥ PHR 5.112D ¥ Austin, Texas
78712-1074
Campus Mail
Code A1900 ¥ TEL (512) 475-9751 ¥ FAX (512) 232-1893 ¥ |
Pharmacotherapy
IIA (PHR 375E)
Spring 2009,
Mondays 9-12 a.m.
Antimicrobials
Module (Whole Course) – First Day Handout
Faculty: Dr. Russell Attridge, Pharm.D.
(Pharmacotherapy)
Dr.
David Burgess, Pharm.D. (Pharmacotherapy)
Dr.
Patrick Davis, Ph.D. (Med Chem),
Course Coordinator
Dr.
Asma Lat, Pharm.D. (Pharmacotherapy)
Dr.
Andrea Mora, Pharm.D. (Pharmacotherapy)
Dr.
Dannielle O'Donnell, Pharm.D. (Pharmacy Practice)
Dr.
Warunee Srisupha-olarn, Pharm.D. (Pharmacotherapy)
Course Texts: 1. Goodman
& Gilman, Pharmacol. Basis of Therapeutics, 11th Edition, 2005.
[Available Online]
2.
Dipiro,
Talbert, Yee, et al. Pharmacotherapy: A Pathophysiologic Approach, 7th. Edition, Appleton & Lange,
2008.
3.
Foye, Principles
of Medicinal Chemistry,
5th (2003) or 6th (2007) Edition Lippincott, 2007.
Note: Exam questions may come from assigned
text or web-based readings.
Web
Resources: 1. The
official Blackboard® web site for this course can be accessed either through UTDirect or
via http://courses.utexas.edu. Either access point is UTEID-protected,
and provides you links to the courses in which you are currently enrolled (make
sure you access the correct Pharmacotherapy course since you are enrolled in three such
courses). You are strongly
encouraged to visit this site for additional resources associated with this
course (your grades, electronic quizzes, powerpoint presentation, previous
exams, the discussion board, contacting faculty by Email, electronic versions
of suggested and required readings and hyperlinks).
The website will also be used
for official, course-related announcements and for exchange class information
and questions via the discussion board.
Be aware that any message posted to the discussion board are available
to all enrolled students and faculty.
If you encounter problems
with accessing Blackboard® please contact the ITS helpdesk at: 512-475-9400 or
the FAQ's at www.utexas.edu/academic/blackboard/answers
2.
You may
also contact faculty members directly via phone or Email.
Dr. Russell Atridge (210-567-8355) rta65@mail.utexas.edu
Dr. David Burgess (210-567-8355) burgessd@uthscsa.edu
Dr. Patrick Davis (475-9751; 892-3660) davispj@mail.utexas.edu
Dr. Asma Lat (210-567-8355) asma.lat@gmail.com
Dr. Andrea Mora (210-567-8355) andrealeigh917@aol.com
Dr. Dannielle O'Donnell (512-248-8099) odonnell@mail.utexas.edu
Dr. Warunee Srisupha-olarn (210-567-8355) srisuphaolaw@uthscsa.edu
Faculty are expected to inform students concerning their office hours
(including electronic office hours, if appropriate) during their first lectures
in the course.
3.
Taped
and video-streamed recordings of lectures are intended to facilitate learning for those
students who find this type of supplementation useful; they are not a substitute for attending class.
Although recordings of these lectures will initially be available to you for
the semester, this is for supplementation only; your instructors expect you to
attend all scheduled lectures. If attendance becomes an issue, videostreaming
availability may be reduced to a two-week period following the lecture. If an individual faculty member chooses
to not make his/her
lectures available by videotape and/or videostreaming, it is that faculty
member's responsibility to so inform you.
It is also faculty prerogative as to whether to administer announced or
unannounced quizzes during lectures (be sure to bring your classroom
response system (CRS) "clickers" to each and every class). If a faculty member chooses to do so,
the points for these quizzes will replace questions on their portion of the
upcoming exam.
Viewing video-streamed
recordings of lectures is primarily intended for on-campus computer facilities
(e.g., LRC Library, 3.116 computer lab, or other computer facilities available
on your specific campus). However,
it should be possible to view the streaming video off-campus using RoadRunner®
or DSL broadband connections. Your
faculty are not in a position to troubleshoot your video-streaming problems, so
please do not ask them to do so; rather, you should access the LRC website at http://www.utexas.edu/pharmacy/resources/lrc
to address those problems. Any
other questions should be directed to the LRC at fudell@mail.utexas.edu.
Spring 2009, Mon
9-12, PHR 3.106
Antimicrobials
Module (Whole Course) – Lecture Schedule
|
Lec |
Faculty |
Date(s) |
Topic |
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0.5 |
Davis |
Jan 26 |
I. Introduction
to the Antimicrobials Module (Road Map) |
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|
|
II. General
Concepts in Antimicrobial Therapy |
|
1.5 |
Davis |
Jan 26 |
A. Resistance Development to Antimicrobials |
|
1.0 |
Davis |
Jan 26 |
B. Classification of Antibiotics a/c Mode of
Action |
|
1.0 |
Burgess |
Feb 2 |
C. Review of Medical Microbiology |
|
1.0 |
Burgess |
Feb 2 |
D. Sensitivity Testing |
|
2.0 |
Burgess |
Feb 2, Feb 9 |
E. General Principles of Antimicrobial Therapy |
|
|
|
|
Exam
1 [February 18th] |
|
|
|
|
|
|
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III. Antimicrobial Classes & Introduction to |
|
8.0 |
Davis |
Feb 9-Feb 23 |
A. Cell Wall Synthesis Inhibitors |
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1. b-Lactam Antibiotics |
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a) Penicillins |
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b) Cephalosporins |
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|
c) Non-Classical b -Lactams |
|
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2. Glycopeptides (vancomycin,
teichoplanin) |
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|
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3. Other Agents (bacitracin,
cycloserine) |
|
3.0 |
Burgess |
Mar 2 |
4. Intro to Clinical Pharmacology of
b-Lactams |
|
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Exam
2 [March 11th] |
|
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3.0 |
Davis |
Mar 9 |
B. Protein Synthesis Inhibitors |
|
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1. Tetracyclines |
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2. Aminoglycosides |
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3. Macrolides |
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4. Other
Agents |
|
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|
Spring Break |
|
|
3.0 |
Burgess |
Mar 23 |
C. Intro to Clinical Pharmacol of Protein Synth
Inhib |
|
1.0 |
Davis |
Mar 30 |
D. Inhibitors of Nucleic Acid Synthesis or
Function |
|
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|
1. Rifampin/Rifabutin |
|
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2. Quinolones |
|
1.0 |
Davis |
Mar 30 |
E. Inhibitors of Folate Synthesis (sulfonamides,
trimethoprim F. Antimicrobials With Other Modes
of Action 1.
Agents
Affecting Membranes 2.
Agents
Affecting Lipopolysaccharides |
|
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|
|
|
2.0 |
Burgess |
Mar 30, Ap 6 |
G. Intro to Clinical Pharmacology 1. Nucleic Acid Agents
2. Folate Inhibitors 3. Agents with Other Mechanisms of
Action |
|
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|
Exam
3 [April 15th] |
|
|
|
|
|
|
1.0 |
Burgess |
Ap 6 |
IV. Intro
to Pharmacodynamics of Antimicrobial Agents |
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V. Therapeutic
Management of Disease States |
|
1.0 |
Burgess |
Ap 6 |
A. Surgical Prophylaxis |
|
1.0 |
Burgess |
Ap `13 |
B. Endocarditis |
|
1.0 |
Attridge |
Ap 13 |
C. Community-Acquired Pneumonia |
|
1.0 |
Burgess |
Ap 13 |
D. Hospital-Acquired Pneumonia |
|
1.0 |
Burgess |
Ap 20 |
E. Upper Respiratory Tract Infections |
|
1.0 |
Burgess |
Ap 20 |
F. Urinary Tract Infections |
|
1.0 |
Srisupha-olarn |
Ap 20 |
G. Tuberculsosis |
|
1.0 |
O'Donnell |
Ap 27 |
H. Sexually Transmitted Diseases |
|
1.0 |
Mora |
Ap 27 |
I. Meningitis |
|
1.0 |
Lat |
Ap 27 |
J. GI & Intra-Abdominal Infections |
|
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|
Exam
4 [May 6th] |
|
1.0 |
Burgess |
May 4 |
K. Skin & Soft Tissue Infections |
|
1.0 |
Burgess |
May 4 |
L. Bone & Joint Infections |
|
1.0 |
Burgess |
May 4 |
M. Sepsis |
|
42 |
|
|
Total Number of Lectures |
Final Exam, which will include Topics
K-M, date to be announced
Pharmacotherapy
IIa (PHR 375E)
Course Policies
Examinations:
There will be four 90 minute
summary examinations throughout the semester, plus a comprehensive final
administered during the Final Exam. Semester exams will be given on Wednesday
mornings from 8:00-9:30 am, in W.C. Hogg
(1.120) according to the following schedule:
|
Exam Date & Time |
Location
|
Coverage
|
Faculty
|
Points
|
|
Wed, Feb 18, 8AM |
WCH 1.120 |
Sec I-II |
Davis, Burgess |
70 |
|
Wed, Mar 11, 8AM |
WCH 1.120 |
Sec IIIA |
Davis, Burgess |
110 |
|
Wed, Ap 15, 8AM |
WCH 1.120 |
Sec IIIB-IIIG |
Davis, Burgess |
100 |
|
Wed, May 6, 8AM |
WCH 1.120 |
Sec IV-VJ |
Burgess, O'Donnell, Attridge, Srisupha-olarn, Mora, Lat |
110 |
|
Final Exam May 13-19 |
TBA |
VK-VM and |
Burgess All Faculty |
30 |
Exam weighting is based upon the number
of lectures applying to that exam (Total = 580 pts). The format and emphasis for exams is entirely the
prerogative of the faculty, irrespective of exam format and emphasis in
previous exams.
It is also faculty prerogative as to
whether to administer announced or unannounced quizzes during lectures (be sure
to bring your classroom response system (CRS) "clickers" to each and every class). If a faculty member chooses to do so,
the points for these quizzes will replace questions on their portion of the
upcoming exam.
Students must arrive on time for examinations.
All instructions and corrections will be made at the beginning of the examination
period and will not be repeated.
Semester exams will begin promptly at the designated hour and will be
picked up after exactly 90 minutes. The final examination will last three
hours. Students arriving after any students have completed the exam and left
the room may not be allowed to sit for the exam, and may receive a score of
zero for the exam.
No allowances will be made for an
exam being missed, other than documented illness or emergency.
The student must contact the course coordinator for confirmation prior
to the exam. If permission is granted to delay the
exam, it is the student responsibility to complete the College Form titled
"Student Request for Alternate Exam Time" for final consideration and final
approval by the Faculty
member. In this event, the nature
of the make-up will be at the discretion of the course coordinator (oral,
written, increased weighting on the final, etc.). An unexcused absence from an exam may result in a grade of "zero"
for that exam.
The grading of objective questions will be based upon the
scantron sheets turned in; i.e., not on answers written on the exam
papers. After the exams have been
graded and an item analysis performed (Measurement & Evaluation Center),
questions may be discarded at the discretion of the Course Coordinator before
arriving at final grades.
Return of Exams; Posting Class Scores & Keys:
Your summary examination and scantron
copy will be returned to you within a reasonable time after taking the
exam. Following the grading of
each exam, the exam key will be posted as an "Announcement" on the Blackboard®
course website. Individual student
scores can be accessed using the Blackboard® "Gradebook" (only you have access
to your grades), and individual grades will not be publicly posted in any
manner.
Post-Exam Remarks and Reconsideration Requests:
If there is a disagreement over the
answer to a specific question, the student should present his/her exam plus a
written explanation (with appropriate documentation) to the instructor within
72 hours of the listserv announcement of posting of the exam results & key
as described above. Documentation
may include statements from textbooks, handouts, packets, or current scientific
reprints; lecture notes are not authoritative documentation. The explanation must be clear, rational, and concise. (This
policy does not apply to addition or other grading errors). Copy the course coordinator (Dr. Davis)
on your email submissions. Note
that faculty are instructed to not respond to reconsideration requests
until the deadline has passed, so do not expect an immediate response to your
request (be patient).
Final Exam Re-Examination Policy:
The re-examination policy for this course will follow the General
Information Catalog (GIC) and College of Pharmacy policies for the University,
which reads as follows: "Only a student who has a grade average of at least
a C on all class work and lab work submitted before the final exam (in this
course, >70% on each exam)
may request a temporary delay of the final course grade because he or
she failed the final examination (i.e., <65%), which is the examination
given during the final exam period as printed in the official examination
schedule. If the petition is denied
by the instructor, the student's final course grade will remain as originally
determined. If the petition is
granted by the instructor, the grade on the reexamination will be substituted for the grade on the original exam in
determining the student's final course grade, provided the student earns at
least a C on the reexamination. If
the grade on the reexamination is less than a C (in this course, <70%),
a final course grade of F must be recorded."
All students who are eligible for
re-examination according to the University criteria specified above will be
notified by the Course Coordinator within 24 hrs of posting the final
examination scores, and must reply within the specified time as to whether
they will be taking the re-examination. Those students who choose to take the re-examination will
be awarded a course grade of "X" until the re-examination is evaluated and the
final course grade computed.
Module Mastery:
Because of the importance of each
and every therapeutic module, a student doing very well on one module while
failing another module (and having an overall average that would be passing) is
no longer acceptable. Students
must pass each and every module with a
grade of at least 70% in order to pass the course. If a module is not passed on the summary exam(s), that
portion of the comprehensive final will be scrutinized to assess whether the
student has finally mastered the material. If the student does not achieve 70% on that portion of the comprehensive final with this second
attempt, a course grade of "F" will be assigned. . If the student does
demonstrate mastery, the score originally attained on the summary exam still
applies (i.e., the first score earned) and will be used to calculate the final
course grade. For those students who do not demonstrate module mastery on
material related to the non-cumulative portion of the final exam, there will be
one makup exam given over just that material. The student must pass this second opportunity to demonstrate
module mastery or a grade of F will be assigned an F in the course. If the student does pass this second opportunity to demonstrate module mastery
(by score 70% or higher), a score of 70% (a minimum passing grade) will be used
in the calculating the module.
The best advice is to achieve a passing score on the module in the first
place, and if not, make sure that you review your errors on the summary exam(s) with the appropriate faculty to
address any deficiencies before the final.
In this particular course, there
is one module (antibacterial chemotherapy), representing the entire course.
Course Grading:
A
= 90 - 100%
B
= 80 - 89%
C
= 70 - 79%
D
= 65 - 69%
F
= Below 65%
This scale may be curved more leniently
in the final analysis of grades at the discretion of the instructors.
Academic Integrity:
The "Statement on Scholastic Integrity
of the College of Pharmacy" reads as follows: "Pharmacy practitioners enjoy a special trust and
authority based upon the profession's commitment to a code of ethical behavior
in its management of client affairs.
The inculcation of a sense of responsible professional behavior is a
critical component of professional education, and high standards of ethical
conduct are expected of pharmacy students. Students who violate University rules on scholastic
dishonesty are subject to disciplinary penalties, including failure of the
course involved and dismissal from the college and/or the University. Since dishonesty harms the individual,
fellow students, and the integrity of the University and the College of
pharmacy, policies of scholastic dishonesty will be strictly enforced in this
class".
Students are expected to work
independently on all examinations. Any student caught cheating will be given an
"zero" on the exam (minimum).
Any student suspected of dishonesty will be reported to the Dean of the College
of Pharmacy and to the Dean of Students, as per University regulations. Students are expected to have read and
understood the current issue of the General Information Catalog published by
the Registrar's Office for information about procedures and about what
constitutes scholastic dishonesty.
Students with Disabilities:
The University
of Texas at Austin provides upon request appropriate academic accommodations
for qualified students with disabilities. All University rules concerning
accommodations must be followed, including the student arranging for special
accommodations prior to each examination.
In the absence of such prearrangement, the student will be assumed that the
student is not requesting special accommodations for that exam, and will be
expected to take the exam with the rest of the class at the regularly scheduled
exam time. For more
information, contact the Office of the Dean of Students at 471-6259, 471-4641 TTY.