Limited Submission Programs - Cancer Prevention and Research Institute of Texas (CPRIT): High-Impact/ High-Risk Research Awards

Summary of Opportunity
Cancer Prevention and Research Institute of Texas (CPRIT): High-Impact/ High-Risk Research Awards [PDF]
OSP Deadline 11/11/14
Funding Agency Deadline 11/17/14 by 3 p.m. CST
Funding or Award Criteria

Program Description:


CPRIT High-Impact/High-Risk (HIHR) Research Awards seek to provide short-term funding to explore the feasibility of high-risk projects that, if successful, would contribute major new insights into the etiology, diagnosis, treatment, or prevention of cancers. Because HIHR Research Awards are designed to support new ideas, preliminary data are not required. Using this mechanism, CPRIT intends to support innovative, developmental projects that focus on exceptionally promising topics that are not yet sufficiently mature to compete successfully for more conventional funding. The HIHR Research Awards are expected to provide the foundation for individual or multiple investigator awards upon completion. Applicants must explain why more conventional sources of support are not available for the proposed research and how short-term funding will lead to strong applications for additional support.

Applications that might be described as"mini-R01s"will not be competitive. The goal of this award mechanism is to fund uncommonly great ideas that merit the opportunity to acquire preliminary data. There should be reasons for the idea to be plausible, but CPRIT acknowledges that most of the selected projects will ultimately fail to meet their primary goals. The rare proposals that succeed will be of sufficient importance to justify this program. Applications may address any research topic related to cancer biology, causation, prevention, detection, screening, or treatment.


Areas of interest include laboratory research, translational studies, population-based and/or clinical investigations. In that cancers arise from a large number of derangements of basic molecular and cellular functions, which, in turn, cause many alterations in basic biological processes, almost any aspect of biology may be relevant to cancer research, more or less directly. The degree of relevance to cancer research will be an important criterion for evaluation of projects for funding by CPRIT (Section 8.3.1). For example, are alterations in the process in question primarily responsible for oncogenesis or secondary manifestations of malignant transformation? Will understanding the process or interfering with it offer selective and useful insight into prevention, diagnosis, or treatment of cancer? Successful applicants for funding from CPRIT will have addressed these questions satisfactorily.


Applicants may request a total of $200,000 for a period of up to 24 months (2 years), inclusive of both direct and indirect costs. Because of the nature of this funding mechanism, renewal applications will not be accepted. Follow-on applications will not be funded until the time requested for the HIHR Research Award has passed. Award funds may be used to pay for salary and benefits, research supplies, equipment, and clinical costs. Requests for funds for travel to scientific meetings are not appropriate for this funding mechanism, nor are requests for funds to support construction and/or renovation. State law limits the amount of award funding that may be spent on indirect costs to no more than 5 percent of the total award amount.

Please see the solicitation for complete information.



Applicable Field(s)  
Number of Nominees Allowed FIVE (5) proposals are allowed from UT Austin
Required Internal Review Documents

Eligible candidates should submit the following materials for Committee Review directly to by 4:30 p.m. on Monday, August 18, 2014:

  1. Dean's or ORU Director's (or Designee's) Letter of Nomination
  2. Two page maximum lay abstract describing the aims of/needs for of the proposed project.  Please mark the top of the page "RESUBMISSION" if that is the nature of the proposed work.
  3. Principal Investigator's short c.v.
Nominee(s) Selected to Advance


Posting Date 09/03/14