Limited Submission Programs - Cancer Prevention and Research Institute of Texas (CPRIT): High-Impact/ High-Risk Research Awards FY 2014

Summary of Opportunity
Cancer Prevention and Research Institute of Texas (CPRIT): High-Impact/ High-Risk Research Awards FY 2014 [PDF]
OSP Deadline 01/28/14
Funding Agency Deadline 02/03/14 by 3 p.m. CST
Funding or Award Criteria

Program Description: CPRIT High-Impact/High-Risk (HIHR) Research Awards seek to provide short-term funding to explore the feasibility of high-risk projects that, if successful, would contribute major new insights into the etiology, diagnosis, treatment, or prevention of cancers. Because HIHR Research Awards are designed to support new ideas, preliminary data are not required. Using this mechanism, CPRIT intends to support innovative, developmental projects that focus on exceptionally promising topics that are not yet sufficiently mature to compete successfully for more conventional funding. The HIHR Research Awards are expected to provide the foundation for individual or multiple investigator awards upon completion. Applicants must explain why more conventional sources of support are not  available for the proposed research and how short-term funding will lead to strong applications for additional support. Applications that might be described as “mini-R01s” will not be competitive. The goal of this award mechanism is to fund uncommonly great ideas that merit the opportunity to acquire preliminary data. There should be reasons for the idea to be plausible, but CPRIT acknowledges  that most of the selected projects will ultimately fail to meet their primary goals. The rare proposals that succeed will be of sufficient importance to justify this program. Applications may address any research topic related to cancer biology, causation, prevention, detection, screening, or treatment.

Areas of interest include laboratory research, translational studies, population-based and/or clinical investigations. In that cancers arise from a large number of derangements of basic molecular and cellular functions, which, in turn, cause many alterations in basic biological processes, almost any aspect of biology may be relevant to cancer research, more or less directly. The degree of relevance to cancer research will be an important criterion for evaluation of projects for funding by CPRIT (Section 8.3.1). For example, are alterations in the process in question primarily responsible for oncogenesis or secondary manifestations of malignant transformation? Will understanding the process or interfering with it offer selective and useful insight into prevention, diagnosis, or treatment of cancer? Successful applicants for funding from CPRIT will have addressed these questions satisfactorily.

Applicants may request a total of $200,000 for a period of up to 24 months (2 years), inclusive of both direct and indirect costs. Because of the nature of this funding mechanism, renewal applications will not be accepted. Award funds may be used to pay for salary and benefits, research supplies, equipment, and clinical costs. Requests for funds for travel to scientific meetings are not appropriate for this funding mechanism, nor are requests for funds to support construction and/or renovation. State law limits the amount of award funding that may be spent on indirect costs to no more than 5 percent of the total award amount.

Please see the solicitation for complete information.



Applicable Field(s)  
Number of Nominees Allowed FIVE (5) proposals are allowed from UT Austin.  NOTE: Individual Investigator Research Awards are a separate solicitation and are NOT limited.
Required Internal Review Documents

Associate Deans or Designates must submit the following materials electronically to no later than 4:30 p.m. on Friday, January 3, 2014

(NOTE: submissions directly from PIs will not be accepted):

  1. Dean's or ORU Director's (or designates) Letter of Nomination with rankings and justification
  2. Two page maximum lay abstract describing the aims of/needs for of the proposed project. 
  3. Principal Investigator's short c.v.

Each College may submit up to 2 (two) internal applications.

Nominee(s) Selected to Advance

Dr. Andrew Ellington, College of Natural Sciences

Dr. George Georgiou, College of Natural Sciences

Dr. Nicholas Peppas, Cockrell School of Engineering

Dr. Kevin Dalby, College of Pharmacy

Dr. Andreas Matouscheck, College of Natural Sciences

Posting Date 12/13/13