Limited Submission Programs - Dana Foundation Program in Brain and Immuno-imaging

Summary of Opportunity
Dana Foundation Program in Brain and Immuno-imaging
OSP Deadline 02/27/12
Funding Agency Deadline 02/28/12 at noon
Funding or Award Criteria

Program Description: The Dana Foundation's imaging research program focuses on improving human brain and brain-immune functioning in health and disease. Funds support pilot-testing by investigators who are early in their research careers of promising but high risk innovative ideas that have direct clinical application and that, when successful, are competitive for larger-scale support from other funders.

This program, as in all Dana research programs, is oriented to the human. Submitted proposals, therefore, should focus on imaging in patients or patient tissues, and healthy volunteers.

Applications for animal model studies of brain conditions or injuries will be considered only if they relate directly to the human but cannot yet feasibly be undertaken in humans, and are anticipated to be translated into the human following the three-year grant period. Such studies that are not undertaken in humans but directly relate to the human include research on: 1) normal brain anatomy and physiology in the animal model that can help to better understand the roles of cells and networks in specific cognitive functions and how these are altered by disease and injury; and 2) animal models of human diseases, either through insertion of human genes or through naturally occurring or induced disease states, that are directly related to the human condition. Specific criteria for these types of studies are listed in the section on Eligibility.

Previously funded studies under this Program have focused primarily on 1) understanding normal brain functioning, how it is altered by disease or injury, and how it recovers or repairs, 2) assessing and improving diagnostic and therapeutic approaches, and 3) refining and advancing imaging technologies to address specific clinical questions. In addition to these three general areas of continued interest, it is becoming increasingly apparent that neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, and mental illnesses such as schizophrenia and depression start long before they are clinically evident. The Foundation, therefore, encourages studies that seek to understand developmental processes of disease, surrogate measures of early disease existence, and measures of disease progression. Also, for chronic traumatic encephalopathy and Alzheimer's disease, the role of tau is becoming of increasing interest and the Foundation is receptive to considering studies on how to image tau.

Please see the solicitation for complete information.

Eligibility

Support is focused on faculty researchers who have demonstrated the potential for independent research careers who are at the assistant professor level, or in the first few years of their associate professor appointments. Post-doctoral fellows are not eligible to apply. Applications from junior investigators that are an extension of the work of a senior mentor, particularly if from the same institution, are discouraged.

Funding of up to $200,000 payable over three years is provided for structural/physiological or cellular imaging proposals from promising early career investigators who have not yet been awarded more than one independent research grant (R01 from the NIH or equivalent from another Federal agency).

Applicable Field(s)  
Number of Nominees Allowed

One (1) preliminary application, using either:

  • Physiological and Structural imaging- anatomical imaging of white or gray matter and measures of physiological functioning. These proposed studies should focus on patient-oriented clinical research.
  • Cellular/ molecular imaging - biochemical actions of specific brain cells, or their interactions with immune cells, which have direct clinical relevance to human health and disease. These studies may involve human tissues or animal models. Applications can involve the study of cells within neural circuits, using a combination of imaging and single cell electrical recording, if the techniques have already been developed.
Required Internal Review Documents

Associate Deans or Designates should submit the following materials electronically to limitedsub@austin.utexas.edu by 4:30 p.m. on Thursday, January 12, 2012:

  1. Dean's or ORU Director's Letter of Nomination
  2. Two-page maximum lay abstract describing the aims/needs of the proposed research project.
  3. The bio sketch/CV of the UT PI

Your College may submit one (1) nomination for consideration.

Notes **Note to Potential Applicants**
Internal review documents do not reflect the application requirements set forth by the sponsor. Please review solicitation carefully.
Nominee(s) Selected to Advance Dr. Boris Zemelman, College of Natural Sciences
Posting Date 12/27/11