Limited Submission Programs - Dana Foundation: 2014 David Mahoney Neuroimaging Program

Summary of Opportunity
Dana Foundation: 2014 David Mahoney Neuroimaging Program
OSP Deadline 02/19/14
Funding Agency Deadline 02/25/14 at Noon
Funding or Award Criteria

Program Description: The Dana Foundation's neuroimaging research program focuses on improving human brain and brain-immune functioning to promote health, and prevent and treat disease. Funds support pilot-testing by investigators who are early in their research careers of promising, high-risk, and innovative ideas with a direct clinical application. Successful studies are then anticipated to be competitive for larger-scale support from other funders.

This program, like all other Dana-supported research, is oriented to improve human health. Investigations, therefore, must be applicable to human brain or brain-immune functioning or malfunctioning to be considered for funding. Submitted proposals should focus on imaging in patients or patient tissues, and healthy volunteers.

Applications for animal model studies of brain conditions or injuries will be considered only if they relate directly to humans but cannot yet feasibly be undertaken in humans, and are anticipated to be translated into human research following the three-year grant period. Such studies include research on: 1) normal brain anatomy and physiology in the animal model that can help to better understand the roles of cells and networks in specific cognitive functions and how these are altered by disease and injury; and 2) animal models of human diseases, either through transgenic methods or through naturally occurring or induced disease states that are directly related to the human condition. Specific criteria for animal model studies are listed in the section on Eligibility.

Previously funded studies under this Program have focused primarily on 1) understanding normal brain functioning, how it is altered by disease or injury, and how it recovers or repairs; 2) assessing and improving diagnostic and therapeutic approaches; and 3) refining and advancing imaging technologies to address specific clinical questions. In addition to these three general areas of continued interest, it is becoming increasingly apparent that neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, and mental illnesses such as schizophrenia and depression start long before they are clinically evident. The Foundation, therefore, encourages studies that seek to understand developmental processes of disease, surrogate measures of early disease existence, and measures of disease progression. Also, for chronic traumatic encephalopathy and Alzheimer's disease, the role of tau is becoming of increasing interest and the Foundation is receptive to considering studies on how to image tau.

Please see the solicitation for complete information.

Eligibility

Support is focused on faculty researchers who have demonstrated the potential for independent research careers who are at the assistant professor level, or in the first few years of their associate professor appointments. Post-doctoral fellows are not eligible to apply. Applications from junior investigators that are an extension of the work of a senior mentor, particularly if from the same institution, are discouraged.

Grant amounts may be up to $200,000 total, payable over three years.

Applicable Field(s)  
Number of Nominees Allowed

One (1) preliminary application, using either:

  • Physiological and Structural imaging- anatomical imaging of white or gray matter and measures of physiological functioning. These proposed studies should focus on patient-oriented clinical research.
  • Cellular/ molecular imaging - biochemical actions of specific brain cells, or their interactions with immune cells, which have direct clinical relevance to human health and disease. These studies may involve human tissues or animal models. Applications can involve the study of cells within neural circuits, using a combination of imaging and single cell electrical recording, if the techniques have already been developed.
Required Internal Review Documents

Associate Deans or Designates should submit the following materials electronically to limitedsub@austin.utexas.edu by 4:30 p.m. Wednesday, January 22, 2014

  1. Dean's or ORU Director's Letter of Nomination
  2. Two-page maximum lay abstract describing the aims/needs of the proposed research project.
  3. The bio sketch/CV of the UT PI

Your College may submit one (1) nomination for consideration.

Notes

Note to Potential Applicants

Internal review documents do not reflect the application requirements set forth by the sponsor. Please review solicitation carefully.

Nominee(s) Selected to Advance  
Posting Date 01/08/13