Current Research Projects in the Lab:
Advanced imagining tools for high-throughput,
high-resolution genetic and drug screening.
In collaboration with Dr. Xiaojing Zhang in the Department of Biomedical Engineering at The University of Texas at Austin we have developed a promising method for rapidly screening live Drosophila embryos for mutations and drugs that disrupt early Drosophila embryonic morphogenesis (Dagani et al., 2007). This technique involves the use of a microfluidic device that automatically positions live embryos within a fluid-filled imaging channel and exposes embryos to defined drug concentrations and constant or biphasic temperature for fixed periods of time. While positioned in the microfluidic device live embryos are imaged by time-lapse DIC microscopy allowing us to assess primary effects on embryogenesis.