Members in the laboratory of R. Adron Harris investigate the structure and function of ion channels with emphasis on the molecular mechanisms responsible for alcohol and drug actions. We are defining the acute actions of alcohol and other drugs on cell signaling as well as the long-term actions that result in tolerance and dependence. Additionly, we study the neurochemical basis for genetic differences in drug response. These experiments use genetically-modified mice that vary in susceptibility to drug intoxication and dependence. Our group also studies anesthetic drugs, pursuing molecular mechanisms responsible for the unconsciousness and amnesia that these drugs produce.
- Effects of drugs on ion channels
- Regulation of gene expression in brain
- Site-directed mutagenesis of ion channels
- Expression of cloned genes in Xenopus oocytes
- Behavioral analysis of ion channels in mutant mice
- Measurement of gene expression in brain
using DNA microarray technology