Selected Publications

  • Blednov YA, Benavidez JM, Geil C, Perra S, Morikawa H, Harris RA. Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice. Brain Behav Immun In press (2011). PubMed
  • Blednov YA, Borghese CM, McCracken ML, Benavidez JM, Geil CR, Osterndorff-Kahanek E, Werner DF, Iyer S, Swihart A, Harrison NL, Homanics GE, Harris RA. Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive alpha2-containing GABA(A) receptors. J Pharmacol Exp Ther 336:145-154 (2011). PubMed
  • Blednov YA, Ponomarev I, Geil C, Bergeson S, Koob GF, Harris RA. Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies. Addict Biol In press (2011). PubMed
  • Gorini G, Bell RL, Mayfield RD. Molecular targets of alcohol action translational research for pharmacotherapy development and screening. Prog Mol Biol Transl Sci 98:293-347 (2011). PubMed
  • Harris RA, Osterndorff-Kahanek E, Ponomarev I, Homanics GE, Blednov YA. Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor alpha1 and alpha2 subunit knock-in mice. Neurosci Lett 488:31-35 (2011). PubMed
  • Mulligan MK, Rhodes JS, Crabbe JC, Mayfield RD, Harris R Adron, Ponomarev I. Molecular Profiles of Drinking Alcohol to Intoxication in C57BL/6J Mice. Alcohol Clin Exp Res 35:659-670 (2011). PubMed
  • Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA. Hybrid mice as genetic models of high alcohol consumption. Behav Genet 40:93-110 (2010). PubMed
  • Ozburn AR, Harris RA, Blednov YA. Behavioral Differences Between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 Hybrid Mice: Relation to Control of Ethanol Intake. Behav Genet 40:551-63 (2010). PubMed
  • Gorini G, Ponomareva O, Shores KS, Person MD, Harris RA, Mayfield RD. Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. FEBS Lett 584:845-851 (2010). PubMed
  • McCracken LM, McCracken ML, Gong DH, Trudell JR, Harris RA. Linking of glycine receptor transmembrane segments three and four allows assignment of intra-subunit-facing residues. ACS Chem Neurosci, 1:482 (2010). PubMed
  • Ponomarev I, Rau V, Eger EI, Harris RA, Fanselow MS. Amygdala Transcriptome and Cellular Mechanisms Underlying Stress-Enhanced Fear Learning in a Rat Model of Posttraumatic Stress Disorder. Neuropsychopharm, 35:1402-11 (2010). PubMed
  • Blednov YA, Walker DL, Iyer SV, Homanics G, Harris RA. Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol. Addict Biol 15:45-61 (2009). PubMed
  • Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA. Hybrid Mice as Genetic Models of High Alcohol Consumption. Behav Genet. 40:93-110 (2009). PubMed
  • McCracken LM, Trudell JR, Goldstein BE, Harris RA, Mihic SJ. Zinc enhances ethanol modulation of the alpha-1 glycine receptor. Neuropharmacology, 58:676-81 (2009). PubMed
  • Blednov YA and Harris RA. Deletion of vanilloid receptor (TRPV1) in mice increases ethanol consumption and decreases sedative actions of ethanol. Neuropharm 56:814-820 (2009). PubMed
  • Mayfield RD and Harris RA. Gene expression profiling in blood: new diagnostics in alcoholism and addiction? Neuropsychopharm 34:250-251 (2009). PubMed
  • Horishita T, Eger EI 2nd and Harris RA. The effects of volatile aromatic anesthetics on voltage-gated Na+ channels expressed in Xenopus oocytes. Anesth Analg 107:1579-1586 (2008). PubMed
  • Harris RA and Eger EI 2nd. Alzheimer’s Disease and Anesthesia: Out of Body, Out of Mind…or Not? Ann Neurol 64:595-597 (2008). PubMed
  • Ozburn AR, Harris RA and Blednov YA. Wheel running, voluntary ethanol consumption, and hedonic substitution. Alcohol 42:417-424 (2008). PubMed
  • Harris RA, Trudell JR and Mihic SJ. Ethanol’s molecular targets. Sci Signal, VoL 1, Issue 28, p. re7 (2008).
  • Zhang Y, Sharma M, Eger EI 2nd, Laste MJ, Hemmings HC and Harris RA. Intrathecal veratridine administration increases MAC in rats. Anesth Analg 107:875-878 (2008). PubMed
  • Horishita T and Harris RA. n-Alcohols inhibit voltage-gated Na+ channels expressed in Xenopus oocytes. J Pharmacol Exp Ther 326:270-7 (2008). PubMed
  • Mayfield RD, Harris RA and Schuckit MA. Genetic factors influencing dependence. Br J of Pharmacology 154:275-87 (2008). InterScience
  • Lobo IA and Harris RA. GABA(A) Receptors and Alcohol. Pharmacology, Pharmacol Biochem Behav 90:90-94 (2008). PubMed
  • Blednov YA and Harris RA. Metabotropic glutamate receptor (mGluR5) regulation of ethanol sedation, dependence and consumption: Relation to acamprosate actions. Int J Neuropsychopharmacol 1:1-19 (2008). PubMed
  • Jenkins A, Lobo IA, Gong D, Trudell JR, Solt K, Harris RA and Eger EI 2nd. General anesthetics have additive actions on three ligand-gated ion channels. Anesth Analg 107:486-93 (2008). PubMed
  • Lobo IA, Harris RA and Trudell JR. Crosslinking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation. J Neurochem 104:1649-62 (2008). PubMed
  • Reilly MT, Lobo IA, McCracken L, Borghese CM, Gong D, Horishita T and Harris RA. Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes. Alcohol Clin Exp Res 32:188-96 (2008). PubMed
  • Blednov YA, Cravatt BF, Boehm SL 2nd, Walker D and Harris RA. Role of endocannabinoids in alcohol consumption and intoxication: Studies of mice lacking fatty acid amide hydrolase. Neuropsychopharmacology 32:1570-82 (2007). PubMed
  • Borghese CM and Harris RA. Studies of ethanol actions on recombinant delta-containing gamma-aminobutyric acid type A receptors yield contradictory results. Alcohol 41:155-62 (2007). PubMed
  • Okvist A, Johansson S, Kuzmin A, Merino R, Ponomarev I, Harris RA, Sheedy D, Garrick T, Harper C, Hurd YL, Terenius L, Ekstrom TJ, Bakalkin G and Yakovleva T. Neuroadaptations in chronic alcoholics: Dysregulation of the NF-kB-dependent gene transcription. PloS ONE 2(9):e930 (2007). PubMed
  • Liu J, Lewohl JM, Harris RA, Dodd PR and Mayfield RD. Altered gene expression profiles in the frontal cortex of cirrhotic alcoholics. Alcohol Clin. Exp. Res. 31:1460-66 (2007). PubMed
  • Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF and Bergeson SE. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PNAS 103, 6368-73 (2006). PubMed
  • Ponomarev I, Maiya R, Harnett MT, Schafer GL, Ryabinin AE, Blednov YA, Morikawa H, Boehm SL 2nd, Homanics GE, Berman A, Lodowski KH, Bergeson SE and Harris RA. Transcriptional signatures of cellular plasticity in mice lacking the α1 subunit of GABAA receptors. J Neurosci 26, 5673-83 (2006). PubMed
  • Liu J, Lewohl JM, Harris RA, Iyer V, Dodd PR, Randall PK and Mayfield RD. Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharm 31, 1574-82 (2006). PubMed
  • Dani JA and Harris RA. Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nature Neurosci 8, 1465-1470 (2005). PubMed
  • Lobo IA, Mascia MP, Trudell JR and Harris RA. Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics. J Biol Chem 279, 33919-27 (2004). PubMed
  • Findlay GS, Phelan R, Roberts MT, Homanics GE, Bergeson SE, Lopreato GF, Mihic SJ, Blednov YA and Harris RA. Glycine receptor knock-in mice and hyperplexia-like phenotypes: comparisons with the null mutant. J. Neurosci 23, 8051-59 (2003). PubMed
  • Maiya R, Buck KJ, Harris RA and Mayfield RD. Ethanol-sensitive sites on the human dopamine transporter. J Biol Chem 277, 30724-9 (2002). PubMed
  • Mascia MP, Trudell JR and Harris RA. Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci USA 97, 9305-10 (2000). PubMed
  • Yamakura T, Mihic SJ and Harris RA. Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors. J Biol Chem 274, 23006-12 (1999). PubMed
  • Wick MJ, Mihic SJ, Ueno S, Mascia MP, Trudell JR, Brozowski SJ, Ye Q, Harrison NL and Harris RA. Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proc Natl Acad Sci USA 95, 6504-9 (1998). PubMed
  • Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA and Harrison NL. Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors. Nature 389, 385-9 (1997). PubMed