Yuri Blednov

Research Interests

My lab designs, produces, and tests novel mutant mice (knock-in and knock-out mice) that delineate genetic and environmental causes of excessive alcohol consumption. Knock-in mice contain a specific gene that is modified or mutated in order to study the effect of the gene on the animals' behavior. In knock-out mice, a specific gene is disabled in order to evaluate its function as a result of its absence. In addition to behavioral studies, I analyze brain samples from these mice using microarray techniques to evaluate ethanol's effect on brain gene expression. My results suggest that the deletion of any genes from this ethanol-sensitive gene “library” may in turn modify the motivation for drinking ethanol. My ultimate goal is to genetically increase the voluntary consumption of alcohol by combining (stacking) several different mutations.

Recent Publications

Ozburn AR, Harris RA, Blednov YA. Behavioral Differences Between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 Hybrid Mice: Relation to Control of Ethanol Intake. Behav Genet. 2010. [Epub ahead of print]. PubMed

Blednov YA, Walker DL, Iyer SV, Homanics G, Harris RA. Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol. Addict Biol 15:45-61 (2010). PubMed

Blednov YA, Ozburn AR, Walker D, Ahmed S, Belknap JK, Harris RA. Hybrid Mice as Genetic Models of High Alcohol Consumption. Behav Genet. 40:93-110 (2010). PubMed

Blednov YA and Harris RA. Deletion of vanilloid receptor (TRPV1) in mice increases ethanol consumption and decreases sedative actions of ethanol. Neuropharm 56:814-820 (2009). PubMed

Ozburn AR, Harris RA and Blednov YA. Wheel running, voluntary ethanol consumption, and hedonic substitution. Alcohol 42:417-424 (2008). PubMed

Mulligan MK, Ponomarev I, Boehm SL 2nd, Owen JA, Levin PS, Berman AE, Blednov YA, Crabbe JC, Williams RW, Miles MF, Bergeson SE. Alcohol trait and transcriptional genomic analysis of C57BL/6 substrains. Genes Brain Behav. 7:677-89 (2008). PubMed

Blednov YA and Harris RA. Metabotropic glutamate receptor (mGluR5) regulation of ethanol sedation, dependence and consumption: Relation to acamprosate actions. Int J Neuropsychopharmacol 1:1-19 (2008). PubMed

Yuri Blednov

  • Research Scientist
  • Section of Neurobiology

Education

  • Ph.D., 1977
  • 2nd Moscow Medical Institute
  • Dr. Sc., 1990
  • Russian Academy of Medical Science

Contact Info