R. Dayne Mayfield

Research Interests

The common goal of my research is to identify the molecular and cellular mechanisms in the central nervous system involved in the psychoactive and addictive properties of drugs of abuse. In addition to a number of collaborative projects allowing me to investigate drug-induced changes in gene expression on a genomic scale, I have developed independent projects focusing on key presynaptic dopaminergic elements that my play a role in the reward and reinforcing effects of ethanol.

Recent Publications

Methner DN, Mayfield RD. Ethanol alters endosomal recycling of human dopamine transporters. J Biol Chem. 285:10310-7 (2010). PubMed

Gorini G, Ponomareva O, Shores KS, Person MD, Harris RA, Mayfield RD. Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. FEBS Lett. 584(5):845-51 (2010). PubMed

Etheridge N, Lewohl JM, Mayfield RD, Harris RA, Dodd PR. Synaptic proteome changes in the superior frontal gyrus and occipital cortex of the alcoholic brain. Proteomics Clin Appl 3:730-742 (2009). PubMed

Bell RL, Kimpel MW, McClintick JN, Strother WN, Carr LG, Liang T, Rodd ZA, Mayfield RD, Edenberg HJ, McBride WJ. Gene expression changes in the nucleus accumbens of alcohol-preferring rats following chronic ethanol consumption. Pharmacol Biochem Behav. 94:131-47 (2009). PubMed

Mayfield RD, Harris RA. Gene expression profiling in blood: new diagnostics in alcoholism and addiction? Neuropsychopharm 34:250-1 (2009). PubMed

Riherd DN, Galindo DG, Krause LR, Mayfield RD. Ethanol potentiates dopamine uptake and increases cell surface distribution of dopamine transporters expressed in SK-N-SH and HEK-293 cells. Alcohol. 42:499-508 (2008). PubMed

Mayfield RD, Harris RA, Schuckit MA. Genetic factors influencing alcohol dependence. Br J Pharmacol. 154:275-87 (2008). PubMed

R. Dayne Mayfield

  • Research Scientist
  • Section of Neurobiology

Education

  • Ph.D., 1990
  • The University of Texas at Austin

Contact Info