Patrick Killion

Research Interests

My research interests focus upon the use of whole-genome technologies such as next-generation sequencing and DNA microarrays to characterize regulatory networks. I have focused upon the study of transcription factor mediated regulation in Saccharomyces cerevisiae through the large-scale analysis of individual transcription factor deletions. Additionally, I have refined protocols and methodologies used to characterize microRNA expression in human cell culture. In this setting I have characterized the regulatory influence the oncogene cMyc has upon microRNA expression. Finally, I come from a background in Software Engineering and have used my knowledge in this area to design and maintain scalable, fault-tolerant bioinformatic infrastructure for the storage and analysis of DNA microarray and sequencing-based data.

Currently, I divide my time between education and research as the leader of the Functional Genomics Research Stream in the Freshman Research Initiative. My research unit is focused upon the use of chromatin immunoprecipitation and next-generation sequencing in order to further characterize transcription factor mediated regulation of the eukaryotic cell cycle.

Recent Publications

Bhinge A*, Killion PJ*, Zheng L, Lee BK, Iyer VR. Suppression of NF-kB translocation and interferon response by miR-22, a Myc-activated microRNA. Manuscript in Submission, 2010

* These authors contributed equally to this work

Killion PJ, Iyer VR. ArrayPlex: distributed, interactive and programmatic access to genome sequence, annotation, ontology, and analytical toolsets. Genome Biol. (2008) vol. 9 (11) pp. R159

Hu Z*, Killion PJ*, Iyer VR. Genetic reconstruction of a functional transcriptional regulatory network. Nature Genetics (2007).

* These authors contributed equally to this work

Killion PJ, Iyer VR. Microarray Data Analysis with the Longhorn Array Database (LAD). Current Protocols in Bioinformatics, December (2004).

Killion PJ, Sherlock G, Iyer VR. The Longhorn Array Database (LAD): An Open-Source, MIAME compliant implementation of the Stanford Microarray Database (SMD). BMC Bioinformatics (2003) vol. 4 pp. 32.

Patrick Killion

  • Research Fellow, Section of Neurobiology
  • Research Educator & Placement Coordinator,
    College of Natural Sciences

Education

  • Ph.D., 2007
  • The University of Texas at Austin

Contact Info