Selected Publications

  • Lobo, IA, Harris, RA and Trudell, JR. Crosslinking of sites involved with alcohol action between transmembrane segments 1 and 3 of the glycine receptor following activation. J. Neurochem., 104:1649-62, 2008. PubMed
  • Reilly, MT, Lobo, IA, McCracken, L, Borghese, CM, Gong, D, Horishita, T, and Harris, RA. Effects of acamprosate on neuronal receptors and ion channels expressed in Xenopus oocytes. Alcohol Clin. Exp. Res., 32:188-96, 2008. PubMed
  • Blednov, YA, Cravatt, BF, Boehm II, SI, Walker, D and Harris, RA. Role of endocannabinoids in alcohol consumption and intoxication: Studies of mice lacking fatty acid amide hydrolase. Neuropsychopharmacology, 32:1570-82, 2007. PubMed
  • Borghese, CM and Harris, RA. Studies of ethanol actions on recombinant delta-containing gamma-aminobutyric acid type A receptors yield contradictory results. Alcohol, 41:155-62 2007. PubMed
  • Okvist, A, Johansson, S, Kuzmin, A, Merino, R, Ponomarev, I, Harris, RA, Sheedy, D, Garrick, T, Harper, C, Hurd, YL, Terenius, L, Ekstrom, TJ, Bakalkin, G, and Yakovleva, T. Neuroadaptations in chronic alcoholics: Dysregulation of the NF-kB-dependent gene transcription. PloS ONE, 2(9):e930, 2007. PubMed
  • Liu, J, Lewohl, JM, Harris, RA, Dodd, PR, Mayfield, RD. Altered gene expression profiles in the frontal cortex of cirrhotic alcoholics. Alcohol Clin. Exp. Res., 31:1460-66, 2007. PubMed
  • Mulligan MK, Ponomarev I, Hitzemann RJ, Belknap JK, Tabakoff B, Harris RA, Crabbe JC, Blednov YA, Grahame NJ, Phillips TJ, Finn DA, Hoffman PL, Iyer VR, Koob GF and Bergeson SE. Toward understanding the genetics of alcohol drinking through transcriptome meta-analysis. PNAS 103, 6368-73 (2006). PubMed
  • Ponomarev I, Maiya R, Harnett MT, Schafer GL, Ryabinin AE, Blednov YA, Morikawa H, Boehm II SL, Homanics GE, Berman A, Lodowski KH, Bergeson SE and Harris RA. Transcriptional signatures of cellular plasticity in mice lacking the α1 subunit of GABAA receptors. J Neurosci 26, 5673-83 (2006). PubMed
  • Liu J, Lewohl JM, Harris RA, Iyer V, Dodd PR, Randall PK and Mayfield RD. Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharm 31, 1574-82 (2006). PubMed
  • Dani JA and Harris RA. Nicotine addiction and comorbidity with alcohol abuse and mental illness. Nature Neurosci 8, 1465-1470 (2005). PubMed
  • Lobo IA, Mascia MP, Trudell JR and Harris RA. Channel gating of the glycine receptor changes accessibility to residues implicated in receptor potentiation by alcohols and anesthetics. J Biol Chem 279, 33919-27 (2004). PubMed
  • Findlay GS, Phelan R, Roberts MT, Homanics GE, Bergeson SE, Lopreato GF, Mihic SJ, Blednov YA and Harris RA. Glycine receptor knock-in mice and hyperplexia-like phenotypes: comparisons with the null mutant. J. Neurosci 23, 8051-59 (2003). PubMed
  • Maiya R, Buck KJ, Harris RA and Mayfield RD. Ethanol-sensitive sites on the human dopamine transporter. J Biol Chem 277, 30724-9 (2002). PubMed
  • Mascia MP, Trudell JR and Harris RA. Specific binding sites for alcohols and anesthetics on ligand-gated ion channels. Proc Natl Acad Sci USA 97, 9305-10 (2000). PubMed
  • Yamakura T, Mihic SJ and Harris RA. Amino acid volume and hydropathy of a transmembrane site determine glycine and anesthetic sensitivity of glycine receptors. J Biol Chem 274, 23006-12 (1999). PubMed
  • Wick MJ, Mihic SJ, Ueno S, Mascia MP, Trudell JR, Brozowski SJ, Ye Q, Harrison NL and Harris RA. Mutations of gamma-aminobutyric acid and glycine receptors change alcohol cutoff: evidence for an alcohol receptor? Proc Natl Acad Sci USA 95, 6504-9 (1998). PubMed
  • Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA and Harrison NL. Sites of alcohol and volatile anaesthetic action on GABAA and glycine receptors. Nature 389, 385-9 (1997). PubMed