Sangeetha Iyer
- Postdoctoral Fellow, Section of Neurobiology
- College of Natural Sciences
Research Interests
I am interested in developing rapid drug discovery paradigms for neurological pathologies. C.elegans is a model system aptly suited to this endeavor due to its pliable genetics. I use numerous screening techniques to sift through libraries of compounds which are then tested for therapeutic effects on worms. I use a combination of molecular biology, electrophysiology and pharmacology to evaluate the molecular basis of action of therapeutic candidates on the worm. This effort will ultimately allow us to discover new drug candidates that will be relevant to human pathological conditions.
Publications
Iyer SV, Benavides RA, Chandra D, Cook JM, Rallapalli S, June HL, Homanics GE. a4 containing GABA A receptors are required for antagonism of ethanol-induced motor incoordintaion and hypnosis by the imidazobenzodiazepine Ro15-4513. Front. Pharmacol. 2(18) (2011). PubMed
Blednov YA, Walker DL, Iyer SV, Homanics G, Harris AR. Mice lacking Gad2 show altered behavioral effects of ethanol, flurazepam and gabaxadol. Addict Biol. 15:45.61 (2010). PubMed
Rau V, Iyer SV, Oh I, Chandra D, Harrison NL, Eger E, Fanselow MS, Homanics GE, Sonner JM. GABAA Receptor a4 Subunit Knockout Mice Are Resistant to the Amnestic Effect of Isoflurane. Anesth Analg. 109 (6): 1816-1822 (2009). PubMed