The common goal of my research is to identify the molecular and cellular mechanisms in the central nervous system involved in the psychoactive and addictive properties of drugs of abuse. In addition to a number of collaborative projects allowing me to investigate drug-induced changes in gene expression on a genomic scale, I have developed independent projects focusing on key presynaptic dopaminergic elements that my play a role in the reward and reinforcing effects of ethanol.
Liu, J, Lewohl, JM, Harris, RA, Dodd, PR, Mayfield, RD. Altered gene expression profiles in the frontal cortex of cirrhotic alcoholics. Alcohol Clin. Exp. Res., 31:1460-66, 2007.
Maiya R, Ponomarev I, Linse KD, Harris RA, and Mayfield RD. Defining the dopamine transporter proteome by convergent biochemical and in silico analyses. Genes Brain Behav. (2006).
Liu J, Lewohl JM, Harris RA, Iyer VR, Dodd PR, Randall PK, and Mayfield RD. Patterns of gene expression in the frontal cortex discriminate alcoholic from nonalcoholic individuals. Neuropsychopharmacology 31, 1574-1582 (2006).
Liu J, Lewohl JM, Dodd PR, Randall PK, Harris RA, and Mayfield RD. Gene expression profiling of individual cases reveals consistent transcriptional changes in alcoholic human brain. J Neurochem 90, 1050-1058 (2004).
Mayfield RD, Lewohl JM, Dodd PR, Herlihy A, Liu J, and Harris R. A. Patterns of gene expression are altered in the frontal and motor cortices of human alcoholics. J Neurochem 81, 802-813 (2002).
Mayfield RD, Maiya R, Keller D, and Zahniser NR. Ethanol potentiates the function of the human dopamine transporter expressed in Xenopus oocytes. J Neurochem 79, 1070-1079 (2001).