My research is focused on understanding differential allosteric modulation of the glycine receptor when activated by agonists with varying degrees of efficacy. I use two-electrode voltage clamp and single-channel patch clamp techniques to investigate the modulatory effects of alcohols, anesthetics, and inhalants on the glycine receptor when activated by full and partial agonists such as glycine, taurine, etc.
Welsh, BT, Kirson D, Allen HM and Mihic SJ. Ethanol enhances taurine-activated glycine receptor function. Alcohol Clin Exp Res. 34:1634-9 (2010). PubMed