Postdoctoral positions are available to study the physiology and drug regulation of neurons in the brain reward circuit, i.e., the mesolimbic dopamine system.
We are currently working on the following three projects.
- Calcium signaling in the brain reward circuit
This project investigates calcium signaling in neurons of the mesolimbic system and its impact on neuronal excitability and plasticity. We are also interested in the regulation of these calcium signals by psychostimulants and other addictive drugs.
(J Neurosci 27:4776-4785, 2007; Neuron 62:826-838, 2009) - Alcohol action on neurons in the brain reward circuit
The goal of this project is to identify the key ion channel species and neurotransmitter systems targeted by alcohol in neurons of the mesolimbic system.
(J Neurophysiol 95:619-626, 2006; J Pharmacol Exp Ther 329:625-633, 2009) - Local microcircuits in the striatum
This project investigates the mechanisms controlling the activity of identified types of neurons in the striatum at the local microcircuit level.
(J Neurosci 28:8682-8690, 2008)
Techniques used in the lab include:
- brain slice electrophysiology
- confocal calcium imaging
- flash photolysis
- optogenetics
- immunohistochemistry
- rodent behavior
Previous experience in at least one of the following techniques is desirable:
- in vitro/in vivo electrophysiology
- calcium imaging
- protein biochemistry
- stereotaxic procedures in rodent brain
PhD or MD is required. The initial appointment will be 2 years with a possibility of extension. The salary will be based on an NIH scale.
If interested, please contact Hitoshi Morikawa.