___________________________________________ PHARMACY ____________________________ --Master of Science in Pharmacy --Doctor of Pharmacy --Doctor of Philosophy Facilities for Graduate Work Research space and modern equipment necessary for sophisticated research are available in a building devoted to pharmaceutical education. The Life Science Library contains approximately 170,000 volumes, including bound journals; additional research facilities include other branch and departmental libraries and the Perry-Castaneda Library. The Drug Dynamics Institute was established at the College of Pharmacy in 1973 as a graduate and postdoctoral research training center where educators, students, scientists, business people, and government officials could come together to share common interests in a wide range of biomedical, pharmaceutical, and public health problems. The mission of the institute is the discovery and communication of scientific and technological knowledge in drug development, manufacturing, marketing, and therapy. Projects in pharmacokinetics and drug metabolism, industrial pharmacy and technology, pharmacology and toxicology, and clinical pharmacy are currently under way. Areas of Study The College of Pharmacy offers graduate study leading to the Master of Science in Pharmacy and doctoral degrees in pharmacy with areas of specialization in four divisions: medicinal chemistry and natural products; pharmacology and toxicology; pharmaceutics, which includes physical pharmacy, biopharmaceutics, and industrial pharmacy; and pharmacy administration. Interdisciplinary courses in neuroscience. Students specializing in neuroscience are referred to a special advisory committee. Additional information is available from the director of the Institute for Neuroscience in care of the College of Pharmacy. Graduate Studies Committees The following faculty members served on Graduate Studies Committees in the spring semester of 1994-1995. MASTER OF SCIENCE IN PHARMACY AND DOCTOR OF PHILOSOPHY PROGRAMS Creed W. Abell Daniel Acosta, Jr. John M. Beale, Jr. Carolyn M. Brown Robert Graves Brown Alan Brooks Combs Kelley A. Cunny Patrick J. Davis Jaime Nabor Delgado James T. Doluisio Carlton K. Erickson Jerry Fineg Rueben A. Gonzales Laurence H. Hurley James P. Kehrer Sean M. Kerwin Serrine S. Lau Kenneth A. Lawson Steven W. Leslie Alfred Martin James W. McGinity Terrence J. Monks Robert S. Pearlman Karen L. Rascati William H. Riffee Marvin D. Shepherd Salomon A. Stavchansky Christian P. Whitman Richard E. Wilcox James P. Wilson DOCTOR OF PHARMACY PROGRAM David S. Burgess Henry I. Bussey Daniel T. Casto Miles Lynn Crismon Larry Ereshefsky James A. Karboski Leroy C. Knodel Jim M. Koeller John G. Kuhn Y. Francis Lam Louis C. Littlefield Robert L. Talbert Admission Requirements The applicant should have a bachelor's degree from an accredited institution in the United States or another country. Students are admitted to the program upon recommendation of the appropriate Graduate Studies Committee, provided that their undergraduate training includes appropriate work in fields related to the pharmaceutical and health sciences. Applicants without the appropriate background may be required to complete additional coursework after admission. Preference is usually given to students who have a Bachelor of Science in Pharmacy degree from a college accredited by the American Council on Pharmaceutical Education. Degree Requirements Pharmacy 296 (Seminar in Pharmacy) is required of all graduate students in pharmacy and is taught every semester in each division. This requirement may be waived for a specific semester by the Graduate Studies Committee for sufficient reasons upon petition by the student's major professor. No more than two semester hours of credit earned in this course are counted toward the number of hours required in master's degree programs. Master of Science in Pharmacy. Students apply for candidacy for the degree the semester in which they expect to graduate. Two semesters in the thesis course, Pharmacy 698, are required; students must be enrolled in Pharmacy 698B the semester they graduate. The Master of Science in Pharmacy with a specialization in pharmacy administration also is offered by a course scheduling option called the Option II Schedule. Pharmacists who are employed full-time may choose to pursue this option. Classes are scheduled on selected Fridays and Saturdays throughout the year; at least two calendar years of study are needed to complete the program. Students must prepare a master's report as part of their course requirements. Doctor of Pharmacy. The general requirements for the Doctor of Pharmacy are given in chapter 3. Doctor of Philosophy. Upon completion of the qualifying examination, the student may apply for admission to candidacy for the doctoral degree. Candidacy is recommended to the graduate dean upon the approval of the program's Graduate Studies Committee. Upon admission to candidacy, the student selects a supervising professor and a dissertation committee is appointed by the graduate dean. A doctoral candidate must designate one area of specialization as a major and must select at least one supporting area outside the College of Pharmacy. For More Information Campus address: Pharmacy Building (PHR) 3.210E, Phone (512) 471- 6590 Mailing address: Graduate Program, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712 WWW: http://saklad.uthscsa.edu/ Graduate Courses (AUSTIN) The faculty expects to offer the following courses in the academic years 1995-1996 and 1996-1997; however, all courses are not taught each semester or summer session. Students should consult the Course Schedule, published before registration, and the supplement to the Course Schedule, published before classes begin, to determine which courses and topics will be offered during a particular semester or summer session. These publications also may reflect changes that have been made to the courses listed here since this catalog was printed. Unless otherwise stated below, each course meets for three lecture hours a week for one semester. PHARMACY: PHR PHR 380D. Structure-Activity Relationships and Mechanisms of Action. Pharmacy 340D and 380D may not both be counted. Prerequisite: Graduate standing. PHR 280E. Communication Skills for Scientists. Only one of the following may be counted: Pharmacy 160H, 260H, 280E. Designed to teach oral communication skills and the basics of scientific writing, including grant applications and manuscripts. Prerequisite: Graduate standing and consent of instructor. Two lecture hours a week for one semester. PHR 380F. Biomedical Pharmacology. Not open to pharmacology majors. Survey of mechanisms of drug action and therapeutic characteristics of key drugs that affect the major organ systems. Prerequisite: Graduate standing and a background in physiology and organic chemistry. PHR 180J, 280J, 380J. Advanced Pharmaceutics: Laboratory Problems. May be repeated for credit. Prerequisite: Graduate standing. Three, six, or nine laboratory hours a week for one semester. PHR 180M, 280M, 380M. Advanced Pharmaceutics. May be repeated for credit when the topics vary. Prerequisite: Graduate standing. The equivalent of one, two, or three lecture hours a week for one semester. PHR 180T. Introduction to Drug Information. Offered on the letter-grade basis only. Knowledge and skills needed to access and interpret drug information. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour a week for one semester. PHR 380N. Selected Aspects of Drug Action. Fundamental concepts of pharmacology, including molecular mechanisms of drug action, absorption, distribution and elimination, tolerance, dependence, mutagenesis, teratogenesis, and carcinogenesis. Prerequisite: Graduate standing and consent of instructor. PHR 381C. Microbial Transformations in Pharmaceutical Chemistry. Application of microorganisms for conducting specific type- reactions of general application; emphasis on methodology, transformations by structural classes, and specific reactions. Prerequisite: Graduate standing and consent of instructor. PHR 381D. Product Development. Pharmacy 351H and 381D may not both be counted. Applications of physical-chemical principles to the formulation and development of stable and bioavailable drug delivery systems. Prerequisite: Graduate standing in the College of Pharmacy. PHR 381E. Advanced Hospital Pharmacy. An in-depth analysis of the operation and administration of the institutional pharmacy and its relationship to the total functioning of the hospital. Prerequisite: Graduate standing. PHR 381G. Advanced Manufacturing Pharmacy. Physical-mechanical properties of compacts, drugs, and polymers. Properties of biodegradable and nonbiodegradable polymers in pharmaceutical formulations. Process validation and pilot plant scale-up. Prerequisite: Graduate standing. PHR 181J, 281J, 381J. Advanced Pharmacy Administration: Laboratory Problems. May be repeated for credit. Prerequisite: Graduate standing. Three, six, or nine laboratory hours a week for one semester. PHR 181M, 281M, 381M. Advanced Pharmacy Administration. May be repeated for credit. Prerequisite: Graduate standing. One, two, or three lecture hours a week for one semester. PHR 381N. Third Party Payment Systems and Managed Health Care. Examination of the classic and contemporary literature on third- party payment systems in health care, with emphasis on pharmacy- related issues. Attention to the advantages, disadvantages, and effects of these systems and of managed health care approaches used by many third-party payers. Prerequisite: Graduate standing. PHR 381P. Health Care Administration. Introduction to the United States health care system and its relationship to pharmacy; comparison with health care in other countries. Prerequisite: Graduate standing. PHR 281T. Advanced Pharmacy Practice Laboratory. Offered on the letter-grade basis only. Preparation for advanced pharmacy practice externships and clerkships. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour and three laboratory hours a week for one semester. PHR 382C. Chemistry of Natural Products. Pharmacy 332C and 382C may not both be counted. The use of microorganisms in type-reactions in synthetic and natural products chemistry and as model systems for predicting mammalian drug metabolism and toxicity; emphasis on methodologies, transformations by structural classes, and control of specific biotransformations. Prerequisite: Graduate standing and consent of instructor. PHR 382G. Selected Topics in Chemotherapeutics. Prerequisite: Graduate standing. PHR 682M. Advanced Biopharmaceutical Analysis. Advanced methods for the determination, isolation, and identification of drugs and their metabolites in biological media. Prerequisite: Graduate standing. Three lecture hours a week for two semesters. PHR 382N. Computer-Assisted Kinetics. Quantitative and simulation treatment of kinetics through computer technology. Topics include protein binding and utilization of program packages such as NONLIN, RSSL, CSMP, SAAM 23, and AUTOAN. Prerequisite: Graduate standing, and Pharmacy 345 or the equivalent. PHR 382R. Recent Advances in Pharmaceutics. Presentation of topics of current research interest in physical pharmacy, biopharmaceutics, and pharmacokinetics. Prerequisite: Graduate standing. PHR 382S. Advanced Biopharmaceutics. Pharmacy 362H and 382S may not both be counted. Provides the student with a more comprehensive background in biopharmaceutics and mathematical techniques used in pharmacokinetics. Prerequisite: Graduate standing and Pharmacy 345. PHR 382V. Pharmaceutical Biotechnology. Applications of protein, oligonucleotide, and related molecules as therapeutic agents: stability, formulation, kinetics, dynamics. Prerequisite: Graduate standing, Chemistry 339K, and Pharmacy 341, 141K, 345, and 145K. PHR 483C. Principles of Pharmacology I. A systematic presentation of pharmacologic agents based on drug- group classification; emphasis on pharmacological mechanisms of action and toxicity. Prerequisite: Graduate standing. Four lecture hours a week for one semester. PHR 483D. Principles of Pharmacology II. Continuation of Pharmacy 483C. Prerequisite: Graduate standing and Pharmacy 483C. Four lecture hours a week for one semester. PHR 383M. Pharmacogenetics. The study of those combined genetic and pharmacological factors that give rise to many unexpected, untoward, and idiosyncratic drug reactions. Prerequisite: Graduate standing, and Pharmacy 473M or the equivalent or consent of instructor. PHR 383N. Solution Theory and Disperse Systems. The theory and technology of solutions and heterogeneous systems; applications of scientific principles to the design of pharmaceutical products; a study of factors influencing physical chemical characteristics, stability, and biopharmaceutical activity of solutions and coarse dispersions; review of recent literature. Prerequisite: Graduate standing and consent of instructor. PHR 383P. Advanced Pharmacokinetics. Study of the kinetics of absorption, distribution, metabolism, and excretion of drugs in the intact organism. Prerequisite: Graduate standing, and Pharmacy 345 or the equivalent. PHR 383R. Rate Processes in Pharmaceutical Systems. A study of decomposition and stabilization of drug molecules in solutions and in solid dosage forms; principles of kinetics and diffusion as applied to pharmaceutical systems. Prerequisite: Graduate standing and consent of instructor. PHR 284K. Advanced Toxicology. Required of pharmacology majors. An organ system approach to advanced topics in general toxicology. Prerequisite: Graduate standing, and some background in pharmacology or consent of instructor. Two lecture hours a week for one semester. PHR 384N. Social Issues in Pharmacy. An examination of the social issues that affect perceptions of illness and medication use, using the theories and concepts of medical sociology. Prerequisite: Graduate standing. PHR 284R. Advances in Molecular Pharmacology. May be repeated for credit when the topics vary. A molecular pharmacological perspective on recent advances in cloning, sequencing, expression, function, and regulation of cell surface receptors. Prerequisite: Graduate standing; and Pharmacy 473K, 483C, 385N, 688QA, 392C, or the equivalent, or consent of instructor. Two lecture hours a week for one semester. PHR 385C. Finding Chemical Information. Pharmacy 355C and 385C may not both be counted. Designed to equip students with an in-depth working knowledge of the extraction of specific chemical and biological information from abstracting and database resources. Prerequisite: Graduate standing. Nine laboratory hours a week for one semester. PHR 185D. Responsible Conduct of Science. Offered on the credit/no credit basis only. Ethical considerations in the conduct of science, including issues of animal welfare, data analysis, fraud, publications, misconduct, intellectual property, grants, peer review, and mentor responsibility. Prerequisite: Graduate standing and consent of instructor. One lecture hour a week for one semester. PHR 385N. Neuropharmacology. Pharmacy 275K and 385N may not both be counted. Required of pharmacology majors. A fundamental course in basic autonomic pharmacology and neuropharmacology, emphasizing methods and neurotransmitter characteristics. Prerequisite: Graduate standing, and Pharmacy 473M or the equivalent. PHR 385R. Advanced Pharmacotherapy I. Offered on the letter-grade basis only. Designed to provide the student with a sound knowledge and comprehension of contemporary therapeutic regimens. Prerequisite: Admission to the Doctor of Pharmacy degree program and credit or registration for Pharmacy 185S. PHR 185S. Advanced Pharmacotherapy I Laboratory. Offered on the letter-grade basis only. Designed to provide the student with an opportunity to communicate knowledge and comprehension of contemporary therapeutic regimens. Prerequisite: Admission to the Doctor of Pharmacy degree program and credit or registration for Pharmacy 385R. Three hours of discussion and case presentation a week for one semester. PHR 285T. Advanced Pharmacotherapy II. Offered on the letter-grade basis only. Continuation of Pharmacy 385R. Prerequisite: Graduate standing, Pharmacy 385R and 185S, and credit or registration for Pharmacy 185U. Two lecture hours a week for one semester. PHR 185U. Advanced Pharmacotherapy II Laboratory. Offered on the letter-grade basis only. Continuation of Pharmacy 185S. Prerequisite: Graduate standing, Pharmacy 385R and 185S, and credit or registration for Pharmacy 285T. Three hours of discussion and case presentation a week for one semester. PHR 386E. Enzymes and DNA as Chemical Targets for Drug Action. Pharmacy 336E and 386E may not both be counted. Chemical and biochemical approaches for studying the interaction of small molecules with enzymes and DNA. Emphasis on chemical aspects of these problems, with some discussion of techniques in molecular biology useful in studies of drug-receptor interactions. Prerequisite: Graduate standing. PHR 386F. The Organic Chemistry of Drug Design and Drug Action. Pharmacy 366F and 386F may not both be counted. The chemical aspects of drug design, development, and action, with emphasis on the molecular mechanisms involved. Prerequisite: Graduate standing in pharmacy, chemistry, or biochemistry, or graduate standing and consent of instructor. PHR 186J, 286J, 386J. Advanced Medicinal Chemistry: Laboratory Techniques. May be repeated for credit. Modern laboratory techniques used in medicinal and natural products chemistry. Prerequisite: Graduate standing. Three, six, or nine laboratory hours a week for one semester. PHR 186K, 286K, 386K. Advanced Medicinal Chemistry. May be repeated for credit. Prerequisite: Graduate standing. The equivalent of one, two, or three lecture hours a week for one semester. PHR 386M. Pharmaceutical Distribution. An in-depth study of the channels of distribution, drug product selection, promotion, pricing, legal and professional environments of the pharmaceutical industry, and pharmacy practice. Prerequisite: Graduate standing. PHR 286N. Advances in the Pharmacological Treatment of Central Nervous System Diseases. May be repeated for credit when the topics vary. Recent advances in the treatment of Parkinson's disease, schizophrenia, depression and bipolar disorder, and Alzheimer's disease. Prerequisite: Graduate standing; and Pharmacy 473K, 483C, 385N, 688QA, 392C, or the equivalent, or consent of instructor. Two lecture hours a week for one semester. PHR 386R. Advances in Receptor Biochemistry. Recent advances in vertebrate receptor biochemistry, with emphasis on the uses of molecular biology in this field. Prerequisite: Graduate standing, Chemistry 392C or the equivalent, and Chemistry 392D or the equivalent. PHR 386S. Molecular Biology of the Nervous System. Pharmacy 336S and 386S may not both be counted. Study of the structure and function of macromolecules in the brain. Prerequisite: Graduate standing, and a course in biochemistry or consent of instructor. PHR 286T. Advanced Nuclear Magnetic Resonance Spectroscopy in Bioorganic Chemistry: Theory and Applications. Problem-based applications of nuclear magnetic resonance to biological chemistry. Advanced study of NMR spectroscopy, including physical principles, pulse methods, and experimental design. Prerequisite: Graduate standing, two semesters of organic chemistry, one semester of physics, and consent of instructor. Two lecture hours a week for one semester. PHR 186U. Advanced Nuclear Magnetic Resonance Spectroscopy Laboratory. Students use high-field nuclear magnetic resonance instrumentation and computer routines to learn techniques and problems in state-of-the-art three-dimensional macromolecular structure determination. Prerequisite: Graduate standing; and credit or registration for Pharmacy 286T, advanced nuclear magnetic resonance training, or consent of instructor. Three laboratory hours a week for one semester. PHR 286V. Advanced Nuclear Magnetic Resonance Spectroscopy in Bioorganic Chemistry: Macromolecular Applications. Expansion of nuclear magnetic resonance concepts discussed in Pharmacy 286T, with emphasis on problems in three-dimensional structure determination in biological macromolecules (carbohydrates, proteins, nucleic acids). Prerequisite: Graduate standing, and Pharmacy 286T or consent of instructor. Two lecture hours a week for one semester. PHR 386W. Stereochemical Aspects of Synthetic Medicinal Chemistry. Pharmacy 368P and 386W may not both be counted. Methods for preparing stereochemically defined compounds for drug development; emphasis on regioselective and stereoselective reactions, use of stereochemically defined compounds from nature, and preparative separation technology. Prerequisite: Graduate standing; and eight hours of organic chemistry and one semester of physical chemistry, or consent of instructor. PHR 387C. Advanced Institutional Pharmacy Management. Management principles, practices, and problems, applied to the pharmacy organization within a health care institution. Prerequisite: Graduate standing and consent of instructor. PHR 387G. Research Design and Grant Writing. Offered on the credit/no credit basis only. Training in the methodology of experiment design and the composition of research grant applications. Prerequisite: Graduate standing and completion of written cumulative examinations in preparation for candidacy for the doctoral degree. PHR 687K. Methods in Drug Evaluation. Prerequisite: For 687KA, graduate standing and Pharmacy 280E (or 180E); for 687KB, Pharmacy 687KA. Nine laboratory hours a week for two semesters. PHR 388C. Introductory Bioorganic Chemistry. Survey of high-field NMR techniques and their applications in bioorganic chemistry. Applications include biosynthesis of natural products, enzyme mechanisms, and drug-DNA interactions. Prerequisite: Graduate standing and Chemistry 391. PHR 388D. Advanced Bioorganic Chemistry. May be repeated for credit when the topics vary. Topics include biosynthesis of natural products, mechanisms of enzymes, and drug- DNA interactions. Prerequisite: Graduate standing. PHR 188J, 288J, 388J. Advanced Pharmacology: Laboratory Problems. May be repeated for credit. Prerequisite: Graduate standing. Three, six, or nine laboratory hours a week for one semester. PHR 188K, 288K, 388K. Advanced Pharmacology. May be repeated for credit when the topics vary. Prerequisite: Graduate standing. The equivalent of one, two, or three lecture hours a week for one semester. PHR 688Q. Principles of Neuroscience I and II. Only one of the following may be counted: Kinesiology 688QA, Pharmacy 688QA, Psychology 688QA, Zoology 688QA; only one of the following may be counted: Kinesiology 688QB, Pharmacy 688QB, Psychology 688QB, Zoology 688QB. A two- semester proseminar covering the core material on essential topics in neuroscience from the molecular to the systems level. Prerequisite: For 688QA, graduate standing and consent of instructor; for 688QB, graduate standing, Pharmacy 688QA or the equivalent, and consent of instructor. Four lecture hours a week for two semesters. PHR 389C. Pharmacy Association Management. Pharmacy 329C and 389C may not both be counted. An introduction to the principles involved in managing pharmacy associations. Prerequisite: Graduate standing and consent of instructor. PHR 689D. Association Management Residency. Pharmacy 629D and 689D may not both be counted. Experience working in a pharmacy association, including active involvement in some managerial aspect of the association. Prerequisite: Graduate standing and consent of instructor. Twenty laboratory hours a week for one semester. PHR 189Q. Seminar in Alcohol Studies. Offered on the credit/no credit basis only. Presentations and discussion of current research topics in alcohol studies. Prerequisite: Graduate standing and consent of instructor. One lecture hour a week for one semester. PHR 390J. Pharmacy Administration Data Analysis. Statistical analysis of research data using the computer and various statistical software programs. Prerequisite: Graduate standing and Pharmacy 390K. Nine laboratory hours a week for one semester. PHR 390K. Experimental Design and Research Methodology in Pharmacy Administration. Principles and procedures of experimental design and research methodology; preexperimental, true, and quasi-experimental designs, reliability, validity, data collection, methods and simulation techniques. Prerequisite: Graduate standing. PHR 490N. Biochemical Toxicology. Discussion of the mechanisms of selected drugs and toxicants. Prerequisite: Graduate standing and Pharmacy 284K (or 384K). Four lecture hours a week for one semester. PHR 390P. Experimental Design and Statistics in Pharmacology. Computer-assisted approach to the solution of design and statistics problems commonly encountered in pharmacological experiments. Prerequisite: Graduate standing, and an introductory statistics course or consent of instructor. Nine laboratory hours a week for one semester. PHR 290R, 390R. Special Problems in Clinical Pharmacy Sciences. May be repeated for credit when the topics vary. Individual supervision of research problems in the clinical pharmacy sciences, including pharmacokinetics, pharmacodynamics, efficacy, safety, and pharmaceutical care. Prerequisite: Graduate standing. For 290R, five laboratory hours a week for one semester; for 390R, nine laboratory hours a week for one semester. PHR 390S. Applied Pharmacokinetics. Offered on the letter-grade basis only. Application of pharmacokinetic principles to specific drugs and patient situations. Prerequisite: Admission to the Doctor of Pharmacy degree program. PHR 392C. Pharmacological Mechanisms I. Advanced course on drug mechanisms; review of literature on several organ systems. Prerequisite: Graduate standing, and Pharmacy 473K or consent of instructor. PHR 392S. Patient Assessment Skills Laboratory. Offered on the credit/no credit basis only. Introduction to patient assessment techniques and to the skills needed to provide pharmaceutical care. Prerequisite: Admission to the Doctor of Pharmacy degree program. Two lecture hours and three laboratory hours a week for one semester. PHR 693. Research in Pharmacy. May be repeated for credit when the topics vary. May not be counted toward the master's degree. Prerequisite: For 693A, graduate standing; for 693B, Pharmacy 693A. The equivalent of three lecture hours a week for two semesters. Topic 1: Research in Medicinal Chemistry. Topic 2: Research in Pharmaceutics. Topic 3: Research in Pharmacology. Topic 4: Research in Pharmacy. Topic 5: Research in Pharmacy Administration. Topic 6: Research in Toxicology. PHR 593C. Acute Care Pharmacy Practice I. Offered on the credit/no credit basis only. Analysis of pharmacotherapy, evaluation of drug use, and synthesis of rational drug regimens in the context of acute patient care. Prerequisite: Graduate standing and Pharmacy 281T. Sixteen laboratory hours a week for one semester. PHR 493D. Computer-Assisted Drug Design. Overview of theory and application of methods useful for computer- assisted drug design, such as molecular orbital calculations, molecular mechanics and dynamics, conformational search, CoMFA, and three-dimensional searching. Hands-on experience with professional-level software and hardware. Prerequisite: Graduate standing, consent of instructor, and an undergraduate course in physical chemistry. Two lecture hours and three laboratory hours a week for one semester. PHR 593E. Elective in Pharmacy Practice I. Offered on the credit/no credit basis only. Experience in pharmacy practice, research, or administration. Prerequisite: Graduate standing and Pharmacy 281T. Forty laboratory hours a week for at least six weeks. PHR 393K. Drugs Affecting the Cardiovascular System. Prerequisite: Graduate standing. PHR 593N. Institutional Pharmacy Practice. Offered on the credit/no credit basis only. Analysis of pharmacotherapy, evaluation of drug use, and synthesis of rational drug regimens in the context of institutional patient care. Prerequisite: Graduate standing and Pharmacy 281T. Forty laboratory hours a week for at least six weeks. PHR 593P. Ambulatory Care Pharmacy Practice. Offered on the credit/no credit basis only. Analysis of pharmacotherapy, evaluation of drug use, and synthesis of rational drug regimens in the context of ambulatory patient care. Prerequisite: Graduate standing and Pharmacy 281T. Forty laboratory hours a week for at least six weeks. PHR 593S. Selective in Pharmacy Practice I. Offered on the credit/no credit basis only. Analysis of pharmacotherapy, evaluation of drug use, and synthesis of rational drug regimens in a selected pharmacy practice environment. Prerequisite: Graduate standing and Pharmacy 281T. Forty laboratory hours a week for at least six weeks. PHR 393T. Pharmacoeconomics. Offered on the letter-grade basis only. Terms, concepts, procedures, methods, problems, and strengths associated with pharmacoeconomics. Prerequisite: Admission to the Doctor of Pharmacy degree program. PHR 594C. Acute Care Pharmacy Practice II. Offered on the credit/no credit basis only. Analysis of pharmacotherapy, evaluation of drug use, and synthesis of rational drug regimens in the context of acute patient care. Prerequisite: Graduate standing and Pharmacy 281T. Sixteen laboratory hours a week for one semester. PHR 394D. Interfacial Phenomena in Pharmaceutics. Phase interfaces, monolayers, bilayers, and nonlamellar surfactant assemblies in terms of thermodynamics, dynamic properties, stability, permeability, and measurement methods. Prerequisite: Graduate standing and a course in physical chemistry. PHR 594E. Elective in Pharmacy Practice II. Offered on the credit/no credit basis only. Experience in pharmacy practice, research, or administration. Prerequisite: Graduate standing and Pharmacy 281T. Forty laboratory hours a week for at least six weeks. PHR 394L. Stereochemical and Regiochemical Aspects of Metabolism. Pharmacy 334L and 394L may not both be counted. Stereochemical concepts and conventions defined in the context of xenobiotic (principally drug) metabolism; methods for conducting and interpreting stereochemical and regiochemical metabolism studies. Prerequisite: Graduate standing and consent of instructor. PHR 394R. Drug Literature Evaluation and Biostatistics. Offered on the letter-grade basis only. Application of statistical principles and evaluation of drug literature, with an emphasis on clinical trials. Prerequisite: Admission to the Doctor of Pharmacy degree program. PHR 594S. Selective in Pharmacy Practice II. Offered on the credit/no credit basis only. Analysis of pharmacotherapy, evaluation of drug use, and synthesis of rational drug regimens in selected pharmacy practice environments. Prerequisite: Graduate standing and Pharmacy 281T. Forty laboratory hours a week for at least six weeks. PHR 395C. Clinical Pharmacology and Therapeutics. Application of pharmacologic and pharmacokinetic principles to drug therapy management in family primary care nursing. Prerequisite: Graduate standing. PHR 395D. Pathophysiology. Nursing 396C and Pharmacy 395D may not both be counted. Structure, function, and mechanisms of disease production in human organ systems. Prerequisite: Graduate standing. PHR 595E. Elective in Pharmacy Practice III. Offered on the credit/no credit basis only. Experience in pharmacy practice, research, or administration. Prerequisite: Graduate standing and Pharmacy 281T. Forty laboratory hours a week for at least six weeks. PHR 395P. Ergogenic Aids for Exercise. Same as Kinesiology 395 (Topic 1: Ergogenic Aids for Exercise). Foundations of human physiology, including cardiovascular, renal, respiratory, muscle, and endocrine physiology. Prerequisite: Graduate standing and consent of instructor. Topics are covered on a level that assumes undergraduate exposure to vertebrate physiology. PHR 296. Seminar in Pharmacy. Offered on the credit/no credit basis only. Students in the Doctor of Pharmacy program may take Pharmacy 296A for independent credit. Prerequisite: Graduate standing in pharmacy. The equivalent of one lecture hour a week for two semesters. PHR 396C. Synthetic Medicinal Chemistry. An organic chemistry approach to drug synthesis based on chemical structures desired or needed for biological intervention. Focus on synthetic methodology useful in carbocyclic and heterocyclic chemistry. Prerequisite: Graduate standing; and one of the following: Chemistry 386J, Pharmacy 396L, 396M, an upper-division course in organic chemistry, or consent of instructor. PHR 596E. Elective in Pharmacy Practice IV. Offered on the credit/no credit basis only. Experience in pharmacy practice, research, or administration. Prerequisite: Graduate standing and Pharmacy 281T. Forty laboratory hours a week for at least six weeks. PHR 396L. Biotechnology in Medical Chemistry: Fundamental Principles and Pharmaceutical Applications. A discussion of the fundamentals and applications of the newer biotechnologies available for the production of drug products. Prerequisite: Graduate standing. PHR 396M. Medicinal Chemistry: General Principles, Pharmacological Classification, and Mechanism of Action. Introduction to medicinal chemistry, covering drug classes according to their pharmacological classification, structural class, and mechanism of action. Prerequisite: Graduate standing and undergraduate coursework in organic chemistry and biochemistry. PHR 196T. Seminar in Toxicology. Offered on the credit/no credit basis only. Presentations and discussion of current research topics in toxicology. Prerequisite: Graduate standing, and admission to the Toxicology Training Program or consent of instructor. One lecture hour a week for one semester. PHR 397C. Pharmacy and Health Care Economics. The economist's approach to pharmacy and health care issues, its insights and disadvantages. Prerequisite: Graduate standing. PHR 397D. Pharmacy Human Resource Management. The elements of supervising pharmacists and technicians in pharmacy environments. Prerequisite: Graduate standing. PHR 397E. Financial Management for Pharmacy Managers. Concepts, principles, and theoretical foundations of financial statements, with emphasis on the pharmacy manager's understanding of accounting procedures and the use of financial statements. Prerequisite: Graduate standing. PHR 397F. Analytical Methods in Pharmacy Management. Computer analytic methods used to derive budget projections, manage purchasing data, and analyze operations research methods of creating and managing projects and systems. Prerequisite: Graduate standing. Three lecture hours and three laboratory hours a week for one semester. PHR 397G. Advanced Community Pharmacy Management. Location analysis, purchasing and financing, layout and design of a pharmacy; merchandising, marketing, and advertising. Prerequisite: Graduate standing. PHR 397J. Advanced Problems in Pharmacy Management. Current problems in community and institutional pharmacy management. Students analyze and prepare a report on a problem in pharmacy management. Prerequisite: Graduate standing. Twelve laboratory hours a week for one semester. PHR 397K. Communication Skills for Pharmacy Managers. Written and oral communication skills and techniques for pharmacists at the managerial level. Prerequisite: Graduate standing. PHR 397M. Drug Design and Synthetic Strategy. A multiperspective approach to modern concepts in drug design and synthetic strategy, including the use of computers and artificial intelligence, with appropriate examples. Prerequisite: Graduate standing; and Chemistry 386J, Pharmacy 396M, or consent of instructor. PHR 698. Thesis. Offered on the letter-grade basis only. Prerequisite: For 698A, graduate standing in pharmacy and consent of the graduate adviser; for 698B, Pharmacy 698A. The equivalent of three lecture hours a week for two semesters. PHR 698K. Hospital Pharmacy Residency. Not less than 1,920 hours of satisfactorily supervised work in an approved hospital pharmacy. A report of the activities of the internship must meet the approval of the student's supervisory committee. Prerequisite: For 698KA, graduate standing in pharmacy and a Bachelor of Science in Pharmacy; for 698KB, Pharmacy 698KA. The equivalent of three lecture hours a week for two semesters. PHR 398R. Master's Report. Offered on the letter-grade basis only. Preparation of a report to fulfill the requirement for the master's degree under the report option. Prerequisite: Graduate standing in pharmacy, admission to the Option II program for the Master of Science in Pharmacy degree, and consent of the graduate adviser. The equivalent of three lecture hours a week for one semester. PHR 398T. Supervised Teaching in Pharmacy. Offered on the credit/no credit basis only. Teaching under close supervision of the faculty; weekly group meetings with the appropriate instructor; individual consultations; semester reports. Prerequisite: Graduate standing. PHR 399R, 699R, 999R. Dissertation. Offered on the letter-grade basis only. Prerequisite: Admission to candidacy for the doctoral degree. PHR 399W, 699W, 999W. Dissertation. Offered on the letter-grade basis only. Prerequisite: Pharmacy 399R, 699R, or 999R. Graduate Courses (SAN ANTONIO) The faculty expects to offer the following courses in the academic years 1995-1996 and 1996-1997. Unless otherwise indicated, each course meets for three lecture hours a week for one semester. PHARMACY: PHR PHR 381R. Preclinical Sciences I. Offered on the credit/no credit basis only. Designed both to accomplish an assessment of student readiness for a rigorous doctoral curriculum and to develop academic preparedness; emphasizes preclinical science fundamentals. Prerequisite: Admission to the Doctor of Pharmacy degree program. PHR 382L. Drug Literature Evaluation. Offered on the letter-grade basis only. Prepares the student for efficient utilization, critical evaluation, and clinical application of the current drug literature. Prerequisite: Admission to the Doctor of Pharmacy degree program. Two lecture hours and three laboratory hours a week for one semester. PHR 283L. Clinical Skills Laboratory. Offered on the letter-grade basis only. Introduction to patient assessment techniques and to the skills needed to provide innovative patient care services. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour and three laboratory hours a week for one semester. PHR 283S. Clinical Toxicology. Offered on the letter-grade basis only. An advanced study of toxicological, pharmaceutical, and pharmacological principles underlying the management of chemical poisoning. Includes analysis of selected cases. Prerequisite: Admission to the Doctor of Pharmacy degree program. Two lecture hours a week for one semester. PHR 184M. Fluids, Electrolytes, Parenteral Nutrition. Offered on the letter-grade basis only. Develops clinical problem- solving capabilities for dealing with fluid, electrolyte, and acid-base imbalances; design of hyperalimentation regimens. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour a week for one semester. PHR 185K. Clinical Pharmacokinetics I. Offered on the letter-grade basis only. Requires student analysis of medicating practices, evaluation of pharmacokinetic phenomena, and synthesis of dosing regimens in structured application of biopharmaceutical principles. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour a week for one semester. PHR 285L. Clinical Pharmacokinetics II. Offered on the letter-grade basis only. Continuation of Pharmacy 185K. Prerequisite: Admission to the Doctor of Pharmacy degree program, and Pharmacy 185K. Two lecture hours a week for one semester. PHR 185M. Clinical Pharmacokinetics III. Offered on the letter-grade basis only. Continuation of Pharmacy 285L. Prerequisite: Admission to the Doctor of Pharmacy degree program, and Pharmacy 285L. One lecture hour a week for one semester. PHR 487P. Pathophysiology I. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of functional changes that accompany disease states. Prerequisite: Admission to the Doctor of Pharmacy degree program. Four lecture hours a week for one semester. PHR 387R. Pathophysiology II. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of functional changes that accompany disease states. Prerequisite: Admission to the Doctor of Pharmacy degree program. PHR 587S. Pathophysiology III. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of functional changes that accompany disease states. Prerequisite: Admission to the Doctor of Pharmacy degree program. Five lecture hours a week for one semester. PHR 387T. Pathophysiology IV. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of functional changes that accompany disease states. Prerequisite: Admission to the Doctor of Pharmacy degree program. PHR 387U. Pathophysiology V. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of functional changes that accompany disease states. Prerequisite: Admission to the Doctor of Pharmacy degree program. PHR 387V. Pathophysiology VI. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of functional changes that accompany disease states. Prerequisite: Admission to the Doctor of Pharmacy degree program. PHR 287W. Pathophysiology VII. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of functional changes that accompany disease states. Prerequisite: Admission to the Doctor of Pharmacy degree program. Two lecture hours a week for one semester. PHR 488U. Pathophysiology and Pharmacotherapeutics of Psychiatric Disorders. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of diagnostic criteria, altered physiologic states, and therapeutic principles of psychiatric illnesses. Prerequisite: Admission to the Doctor of Pharmacy degree program. Four lecture hours a week for one semester. PHR 189E. Advanced Pharmacotherapeutics of Musculoskeletal Disorders. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of contemporary therapeutic regimens used in the treatment of diseases involving the musculoskeletal system. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour a week for one semester. PHR 289F. Advanced Pharmacotherapeutics of Neurological Disorders. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of contemporary therapeutic principles used in treating neurological diseases. Prerequisite: Admission to the Doctor of Pharmacy degree program. Two lecture hours a week for one semester. PHR 189G. Advanced Pharmacotherapeutics of Endocrine Disorders. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of contemporary therapeutic regimens used in treating endocrine disorders. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour a week for one semester. PHR 189H. Advanced Pharmacotherapeutics of Gastrointestinal Disorders. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of contemporary therapeutic regimens used in treating gastrointestinal disorders. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour a week for one semester. PHR 289J. Advanced Pharmacotherapeutics of Cardiovascular Disorders. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of contemporary pharmacotherapeutic regimens used in treating cardiovascular diseases. Prerequisite: Admission to the Doctor of Pharmacy degree program. Two lecture hours a week for one semester. PHR 189L. Advanced Pharmacotherapeutics of Renal Disorders. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of contemporary therapeutic regimens used in treating renal diseases and associated disorders. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour a week for one semester. PHR 189M. Advanced Pharmacotherapeutics of Pulmonary Disorders. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of contemporary therapeutic regimens used in treating pulmonary diseases. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour a week for one semester. PHR 189N. Advanced Pharmacotherapeutics of Reproductive Disorders. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of contemporary therapeutic regimens used in treating reproductive disorders and problems in conception. Prerequisite: Admission to the Doctor of Pharmacy degree program. One lecture hour a week for one semester. PHR 289P. Advanced Pharmacotherapeutics of Infectious Diseases I. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of contemporary therapeutic principles used in treating infectious diseases. Prerequisite: Admission to the Doctor of Pharmacy degree program. Two lecture hours a week for one semester. PHR 389S. Advanced Pharmacotherapeutics of Hematology/Oncology. Offered on the letter-grade basis only. Provides the student with a sound knowledge and comprehension of contemporary therapeutic principles used in treating hematologic and malignant diseases. Prerequisite: Admission to the Doctor of Pharmacy degree program. PHR 291K, 391K, 491K. Clinical Rotation I. Offered on the credit/no credit basis only. With consent of the graduate adviser, may be repeated for credit. Requires student analysis and evaluation of clinical drug literature, synthesis of comparative drug product reviews, technical writing competence, and effective clinical practitioner support. Prerequisite: Admission to the Doctor of Pharmacy degree program and consent of the supervising professor. Six, nine, or twelve laboratory hours a week for one semester. PHR 291L, 391L, 491L. Clinical Rotation II. Offered on the credit/no credit basis only. With consent of the graduate adviser, may be repeated for credit. Requires student analysis of pharmacotherapeutic practices, evaluation of drug utilization, and synthesis of rational drug regimens in the context of ambulatory patient care. Prerequisite: Admission to the Doctor of Pharmacy degree program and consent of the supervising professor. Six, nine, or twelve laboratory hours a week for one semester. PHR 291M, 391M, 491M. Clinical Rotation III. Offered on the credit/no credit basis only. With consent of the graduate adviser, may be repeated for credit. Requires student analysis of pharmacotherapeutic practices, evaluation of drug utilization, and synthesis of rational drug regimens in the context of pediatric patient care. Prerequisite: Admission to the Doctor of Pharmacy degree program and consent of the supervising professor. Six, nine, or twelve laboratory hours a week for one semester. PHR 291N, 391N, 491N. Clinical Rotation IV. Offered on the credit/no credit basis only. With consent of the graduate adviser, may be repeated for credit. Requires student analysis of pharmacotherapeutic practices, evaluation of drug utilization, and synthesis of rational drug regimens in the context of psychiatric patient care. Prerequisite: Admission to the Doctor of Pharmacy degree program and consent of the supervising professor. Six, nine, or twelve laboratory hours a week for one semester. PHR 291P, 391P, 491P. Clinical Rotation V. Offered on the credit/no credit basis only. With consent of the graduate adviser, may be repeated for credit. Requires student analysis of pharmacotherapeutic practices, evaluation of drug utilization, and synthesis of rational drug regimens in the context of acute patient care. Prerequisite: Admission to the Doctor of Pharmacy degree program and consent of the supervising professor. Six, nine, or twelve laboratory hours a week for one semester. PHR 291R, 391R, 491R. Clinical Rotation VI. Offered on the credit/no credit basis only. With consent of the graduate adviser, may be repeated for credit. Continuation of Pharmacy 291P, 391P, 491P, but in a different acute medical service area. Prerequisite: Admission to the Doctor of Pharmacy degree program and consent of the supervising professor. Six, nine, or twelve laboratory hours a week for one semester. PHR 291T, 391T, 491T. Clinical Rotation VIII. Offered on the credit/no credit basis only. With consent of the graduate adviser, may be repeated for credit. Requires student analysis of clinical pharmacokinetic data, evaluation of laboratory findings, and synthesis of rational dosing regimens. Prerequisite: Admission to the Doctor of Pharmacy degree program. Six, nine, or twelve laboratory hours a week for one semester. PHR 291V, 391V, 491V. Clinical Rotation IX. Offered on the credit/no credit basis only. With consent of the graduate adviser, may be repeated for credit. Experiential component of curriculum designed for special clinical training in subspecialty clinics and acute care facilities. Prerequisite: Admission to the Doctor of Pharmacy degree program. Six, nine, or twelve laboratory hours a week for one semester. PHR 492K. Doctor of Pharmacy Practicum I. Offered on the credit/no credit basis only. Provides a professional service and teaching challenge, allowing the student to demonstrate doctoral-level proficiency in applying preclinical sciences to patient care. Prerequisite: Completion of clinical rotation series and consent of the student's dissertation committee. Sixteen laboratory hours a week for one semester. PHR 492L. Doctor of Pharmacy Practicum II. Offered on the credit/no credit basis only. Continuation of Pharmacy 492K. Prerequisite: Completion of clinical rotation series and consent of the student's dissertation committee. Sixteen laboratory hours a week for one semester. PHR 492M. Doctor of Pharmacy Practicum III. Offered on the credit/no credit basis only. Continuation of Pharmacy 492L. Prerequisite: Completion of clinical rotation series and consent of the student's dissertation committee. Sixteen laboratory hours a week for one semester. PHR 492N. Doctor of Pharmacy Practicum IV. Offered on the credit/no credit basis only. Continuation of Pharmacy 492M. Prerequisite: Completion of clinical rotation series and consent of the student's dissertation committee. Sixteen laboratory hours a week for one semester. PHR 492P. Doctor of Pharmacy Practicum V. Offered on the credit/no credit basis only. Continuation of Pharmacy 492N. Prerequisite: Completion of clinical rotation series and consent of the student's dissertation committee. Sixteen laboratory hours a week for one semester. PHR 492R. Doctor of Pharmacy Practicum VI. Offered on the credit/no credit basis only. Continuation of Pharmacy 492P. Prerequisite: Completion of clinical rotation series and consent of the student's dissertation committee. Sixteen laboratory hours a week for one semester. Topic 1: Research in Medicinal Chemistry. Topic 2: Research in Pharmaceutics. Topic 3: Research in Pharmacology. Topic 4: Research in Pharmacy. Topic 5: Research in Pharmacy Administration. Topic 6: Research in Toxicology.