Carbohydrates are critical in a myriad of important biological processes including intra-cellular communication, inflammation and bacterial and viral infections. Despite mounting evidence for the impact of glycosylation in modern biology, in vivo functional studies of these posttranslational modifications are not readily carried out. This is in part due to a lack of the appropriate tools. The Mahal Lab merges chemistry and biology to create new methods for the study of glycosylation. These include the creation and utilization of inhibitors, cellular sensors and new array technologies. The Lab focuses on two major areas of interest: 1. Creation of tools for the study of ?-O-N-acetyl-D-glucosamine function, a cytosolic carbohydrate modification analogous to phosphorylation. and 2. Systems-based study of glycosylation.
Affiliated Research Units
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