The problem we face when we try to study the mammalian brain is given by the high interconnectivity between neurons. A functionally closed system thus consists of hundreds of thousands of neurons. At the same time nonlinear processes in the smallest subcellular compartments can have a decisive impact on the output of the whole network. We thus face the challenge of having to observe a large number of neurons, and at the same time their small parts of neurons.
The focus of this lab is thus to use existing tools and develop new ones in order to achieve this goal. One of the methods used is two-photon imaging in combination with electrophysiology. This method allows us to image opaque tissue like the mammalian brain. Recently we were able to record from the individual synapses between pairs of neurons.
Using these methods we will examine the contribution of nonlinear dendritic processes to network information processing and to the information transformation within a cascade of networks.
Affiliated Research Units
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