Dr. Frei's translational research activities involve the application and critical evaluation of novel technologies (including anti-infectives) in both institutional and community healthcare settings. His approach can best be described as a mixture of pharmacoepidemiology, health services research, health disparities research, and microbial genomics. The major focuses are pneumonia, methicillin-resistant Staphylococcus aureus (MRSA), HIV, and influenza.