Director, Drug Dynamics Institute
Improving Bioavailability of Poorly Water Soluble Drugs – It is commonly cited that nearly 40% of new compounds identified for therapeutic use exhibit poor aqueous solubility. Many techniques have been used to improve water solubility including particle size reduction, solid dispersion processes, molecular complexation, and self emulsifying systems. Of particular interest is the stabilization of amorphous drug in a suitable pharmaceutical carrier to improve drug solubility and, ultimately, bioavailability.
Efficacy Studies in Preclinical Models of Airway Disease – Prior to conducting clinical trials for a new inhaled therapy, the drug product must be proven efficacious in one or more animal models. New treatments for airway disease are typically evaluated in a sensitized rodent model that will exhibit pulmonary inflammation and constriction similar to that encountered in asthma and COPD. A better understanding of the effects of novel formulations, methods of dose administration, sensitization, and response quantification are needed in these models.
Pharmacotherapy to Prolong Allograft Survival in Transplant Recipients – Following organ transplant, patients are prescribed a multi-drug regimen consisting of immunosuppressive drugs such as corticosteroids, calcineurin inhibitors, and antimetabolites. These transplant therapies are often complicated by opportunistic infection and reduction in patient quality of life due to untoward side effects. Advanced drug formulation and delivery to localize therapy and reduce side effects shows potential to improve outcomes of lung transplant recipients.
Affiliated Research Units
Now that you've used EUREKA to identify a faculty member whose research interests match your own, read about getting involved in research at The University of Texas at Austin.
The Office of Undergraduate Research recommends that you attend an info session before contacting faculty members about research opportunities. We'll cover the steps to getting involved, tips for contacting faculty, funding possibilities, and options for course credit.
If you aren't able to attend an info session, contact the Office of Undergraduate Research to schedule an appointment with an advisor.